Peptide Vaccine Against Paracoccidioidomycosis
Vaccines for Invasive Fungal Infections
Methods in molecular biology, January 2017
Carlos P. Taborda, Luiz R. Travassos, Taborda, Carlos P., Travassos, Luiz R.
Markus Kalkum, Margarita Semis
The chapter reviews methods utilized for the isolation and characterization of a promising immunogen candidate, aiming at a human vaccine against paracoccidioidomycosis. Peptide P10 carries a T-CD4+ epitope and was identified as an internal sequence of the major diagnostic antigen known as gp43 glycoprotein. It successfully treated massive intratracheal infections by virulent Paracoccidioides brasiliensis in combination with chemotherapy.An introduction about the systemic mycosis was found essential to understand the various options that were considered to design prophylactic and therapeutic vaccine protocols using peptide P10.
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