Chapter title |
Yeast Expressing Gp43 Protein as a Vaccine Against Paracoccidioides brasiliensis Infection
|
---|---|
Chapter number | 14 |
Book title |
Vaccines for Invasive Fungal Infections
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-7104-6_14 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7103-9, 978-1-4939-7104-6
|
Authors |
Aline Ferreira Oliveira, Paulo S. R. Coelho |
Editors |
Markus Kalkum, Margarita Semis |
Abstract |
Paracoccidioidomycosis (PCM) represents the most frequent systemic mycosis in Latin American. The disease is caused by the pathogenic thermally dimorphic fungus Paracoccidioides brasiliensis, and is initially characterized by pulmonary lesions, which can subsequently disseminate to other organs, resulting in secondary injuries. Although its high incidence, there is no commercially available vaccine against fungal diseases. A novel strategy, using Saccharomyces cerevisiae yeast as a vehicle for immunization against PCM, was recently successfully described. Herein, we describe strategies for the construction of the suitable S. cerevisiae vaccine, and protocols of administration and evaluation of the efficacy of the vaccine against experimental PCM. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 6 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 2 | 33% |
Professor | 1 | 17% |
Student > Doctoral Student | 1 | 17% |
Researcher | 1 | 17% |
Professor > Associate Professor | 1 | 17% |
Other | 0 | 0% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 2 | 33% |
Immunology and Microbiology | 2 | 33% |
Engineering | 1 | 17% |
Unknown | 1 | 17% |