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Sildenafil ameliorates oxidative stress and DNA damage in the stenotic kidneys in mice with renovascular hypertension

Overview of attention for article published in Journal of Translational Medicine, February 2014
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2 X users

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41 Dimensions

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49 Mendeley
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Title
Sildenafil ameliorates oxidative stress and DNA damage in the stenotic kidneys in mice with renovascular hypertension
Published in
Journal of Translational Medicine, February 2014
DOI 10.1186/1479-5876-12-35
Pubmed ID
Authors

Ananda T Dias, Bianca P Rodrigues, Marcella L Porto, Agata L Gava, Camille M Balarini, Flavia P S Freitas, Zaira Palomino, Dulce E Casarini, Bianca P Campagnaro, Thiago M C Pereira, Silvana S Meyrelles, Elisardo C Vasquez

Abstract

Oxidative stress and DNA damage have been implicated in the pathogenesis of renovascular hypertension induced by renal artery stenosis in the two-kidney, one-clip (2K1C) Goldblatt model. Considering our previous report indicating that the chronic blockade of phosphodiesterase 5 with sildenafil (Viagra) has marked beneficial effects on oxidative stress and DNA damage, we tested the hypothesis that sildenafil could also protect the stenotic kidneys of 2K1C hypertensive mice against oxidative stress and genotoxicity.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Korea, Republic of 1 2%
Unknown 48 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 14%
Student > Bachelor 5 10%
Student > Ph. D. Student 4 8%
Other 3 6%
Student > Doctoral Student 3 6%
Other 14 29%
Unknown 13 27%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 24%
Medicine and Dentistry 9 18%
Pharmacology, Toxicology and Pharmaceutical Science 5 10%
Biochemistry, Genetics and Molecular Biology 3 6%
Neuroscience 2 4%
Other 5 10%
Unknown 13 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 May 2020.
All research outputs
#14,773,697
of 22,743,667 outputs
Outputs from Journal of Translational Medicine
#1,971
of 3,976 outputs
Outputs of similar age
#182,423
of 307,252 outputs
Outputs of similar age from Journal of Translational Medicine
#57
of 116 outputs
Altmetric has tracked 22,743,667 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,976 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,252 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 116 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.