↓ Skip to main content

Population Pharmacokinetics of Tigecycline in Critically Ill Patients with Severe Infections

Overview of attention for article published in Antimicrobial Agents and Chemotherapy, June 2017
Altmetric Badge

Mentioned by

twitter
3 tweeters

Citations

dimensions_citation
4 Dimensions

Readers on

mendeley
17 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Population Pharmacokinetics of Tigecycline in Critically Ill Patients with Severe Infections
Published in
Antimicrobial Agents and Chemotherapy, June 2017
DOI 10.1128/aac.00345-17
Pubmed ID
Authors

Jiao Xie, Jason A. Roberts, Abdulaziz S. Alobaid, Claire Roger, Yan Wang, Qianting Yang, Jinyao Sun, Haiyan Dong, Xue Wang, Jianfeng Xing, Jeffrey Lipman, Yalin Dong

Abstract

Objectives: We sought to describe the population pharmacokinetics of tigecycline in critically ill patients and describe optimized dosing regimens of tigecycline for different bacterial infections.Methods: This prospective study included ten critically ill patients given a standard dose of tigecycline. Blood samples were collected during one dosing interval and analyzed using validated chromatography. Population pharmacokinetics and Monte Carlo dosing simulations were undertaken using Pmetrics. Three target exposures, ratios of 24h area under the curve to minimum inhibitory concentrations (AUC0-24/MIC), were evaluated (≥17.9 for skin infections, ≥6.96 for intraabdominal infections, ≥4.5 for hospital-acquired pneumonia).Results: The median age, total body weight and body mass index (BMI) were 67 years, 69.1 kg and 24.7 kg/m(2), respectively. A two-compartment linear model best described the time course of tigecycline concentrations. The mean±SD parameter estimates from the final model were clearance 7.50±1.11 L/h, volume of central compartment 72.50±21.18 L, rate constant for tigecycline distribution from the central to peripheral compartment 0.31±0.16 h(-1) and from the peripheral to central compartment 0.29±0.30 h(-1) A larger BMI was associated with increased CL of tigecycline. Licensed doses were found to be sufficient for Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, and Methicillin-resistant Staphylococcus aureus for an AUC0-24/MIC target of 4.5 or 6.96. For a therapeutic target of 17.9, an increase tigecycline dose is required, especially for patients with higher BMI.Conclusion: Dosing requirements of tigecycline differ with indication, pathogen susceptibility and potentially with patient BMI.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 18%
Student > Bachelor 3 18%
Lecturer 2 12%
Researcher 2 12%
Student > Doctoral Student 2 12%
Other 5 29%
Readers by discipline Count As %
Unspecified 6 35%
Pharmacology, Toxicology and Pharmaceutical Science 4 24%
Medicine and Dentistry 3 18%
Computer Science 1 6%
Immunology and Microbiology 1 6%
Other 2 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 June 2017.
All research outputs
#8,759,503
of 11,379,716 outputs
Outputs from Antimicrobial Agents and Chemotherapy
#8,911
of 10,165 outputs
Outputs of similar age
#176,114
of 267,365 outputs
Outputs of similar age from Antimicrobial Agents and Chemotherapy
#255
of 279 outputs
Altmetric has tracked 11,379,716 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,165 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,365 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 279 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.