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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Stem cell models of Alzheimer’s disease: progress and challenges
|
|---|---|
| Published in |
Alzheimer's Research & Therapy, June 2017
|
| DOI | 10.1186/s13195-017-0268-4 |
| Pubmed ID | |
| Authors |
Charles Arber, Christopher Lovejoy, Selina Wray |
| Abstract |
A major challenge to our understanding of the molecular mechanisms of Alzheimer's disease (AD) has been the lack of physiologically relevant in vitro models which capture the precise patient genome, in the cell type of interest, with physiological expression levels of the gene(s) of interest. Induced pluripotent stem cell (iPSC) technology, together with advances in 2D and 3D neuronal differentiation, offers a unique opportunity to overcome this challenge and generate a limitless supply of human neurons for in vitro studies. iPSC-neuron models have been widely employed to model AD and we discuss in this review the progress that has been made to date using patient-derived neurons to recapitulate key aspects of AD pathology and how these models have contributed to a deeper understanding of AD molecular mechanisms, as well as addressing the key challenges posed by using this technology and what progress is being made to overcome these. Finally, we highlight future directions for the use of iPSC-neurons in AD research and highlight the potential value of this technology to neurodegenerative research in the coming years. |
X Demographics
The data shown below were collected from the profiles of 27 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 14 | 52% |
| United States | 3 | 11% |
| Unknown | 10 | 37% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 52% |
| Scientists | 9 | 33% |
| Practitioners (doctors, other healthcare professionals) | 2 | 7% |
| Science communicators (journalists, bloggers, editors) | 2 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 419 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 419 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 78 | 19% |
| Student > Bachelor | 61 | 15% |
| Researcher | 55 | 13% |
| Student > Master | 47 | 11% |
| Student > Doctoral Student | 18 | 4% |
| Other | 43 | 10% |
| Unknown | 117 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 80 | 19% |
| Neuroscience | 75 | 18% |
| Agricultural and Biological Sciences | 54 | 13% |
| Engineering | 18 | 4% |
| Medicine and Dentistry | 17 | 4% |
| Other | 46 | 11% |
| Unknown | 129 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 33. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 January 2018.
All research outputs
#1,203,417
of 25,250,629 outputs
Outputs from Alzheimer's Research & Therapy
#158
of 1,441 outputs
Outputs of similar age
#23,919
of 323,720 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#3
of 20 outputs
Altmetric has tracked 25,250,629 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,441 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.6. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,720 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.