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Modulation of inflammation in transgenic models of Alzheimer’s disease

Overview of attention for article published in Journal of Neuroinflammation, February 2014
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

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1 news outlet
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2 X users

Citations

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103 Dimensions

Readers on

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173 Mendeley
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Title
Modulation of inflammation in transgenic models of Alzheimer’s disease
Published in
Journal of Neuroinflammation, February 2014
DOI 10.1186/1742-2094-11-25
Pubmed ID
Authors

Amy M Birch, Loukia Katsouri, Magdalena Sastre

Abstract

Over the past decade the process of inflammation has been a focus of increasing interest in the Alzheimer's disease (AD) field, not only for its potential role in neuronal degeneration but also as a promising therapeutic target. However, recent research in this field has provided divergent outcomes, largely due to the use of different models and different stages of the disease when the investigations have been carried out. It is now accepted that microglia, and possibly astrocytes, change their activation phenotype during ageing and the stage of the disease, and therefore these are important factors to have in mind to define the function of different inflammatory components as well as potential therapies. Modulating inflammation using animal models of AD has offered the possibility to investigate inflammatory components individually and manipulate inflammatory genes in amyloid precursor protein and tau transgenics independently. This has also offered some hints on the mechanisms by which these factors may affect AD pathology. In this review we examine the different transgenic approaches and treatments that have been reported to modulate inflammation using animal models of AD. These studies have provided evidence that enhancing inflammation is linked with increases in amyloid-beta (Aβ) generation, Aβ aggregation and tau phosphorylation. However, the alterations on tau phosphorylation can be independent of changes in Aβ levels by these inflammatory mediators.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 173 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Chile 1 <1%
Ghana 1 <1%
India 1 <1%
China 1 <1%
United States 1 <1%
Unknown 167 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 34 20%
Researcher 32 18%
Student > Master 32 18%
Student > Bachelor 22 13%
Student > Doctoral Student 9 5%
Other 23 13%
Unknown 21 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 44 25%
Neuroscience 39 23%
Biochemistry, Genetics and Molecular Biology 19 11%
Medicine and Dentistry 13 8%
Pharmacology, Toxicology and Pharmaceutical Science 7 4%
Other 22 13%
Unknown 29 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2018.
All research outputs
#3,023,042
of 22,743,667 outputs
Outputs from Journal of Neuroinflammation
#507
of 2,617 outputs
Outputs of similar age
#36,711
of 307,468 outputs
Outputs of similar age from Journal of Neuroinflammation
#7
of 61 outputs
Altmetric has tracked 22,743,667 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,617 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,468 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.