Title |
Five Unprecedented Secondary Metabolites from the Spider Parasitic Fungus Akanthomyces novoguineensis
|
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Published in |
Molecules, June 2017
|
DOI | 10.3390/molecules22060991 |
Pubmed ID | |
Authors |
Soleiman E. Helaly, Wilawan Kuephadungphan, Souwalak Phongpaichit, Janet Jennifer Luangsa-ard, Vatcharin Rukachaisirikul, Marc Stadler |
Abstract |
Five new compounds including the glycosylated β-naphthol (1, akanthol), a glycosylated pyrazine (2, akanthozine), and three amide derivatives including a hydroxamic acid derivative (3-5) were isolated from the spider-associated fungus Akanthomyces novoguineensis (Cordycipitaceae, Ascomycota). Their structures were elucidated by using high resolution mass spectrometry (HRMS) and NMR spectroscopy. In this study, the antimicrobial, cytotoxic, anti-biofilm, and nematicidal activities of the new compounds were evaluated. The distribution pattern of secondary metabolites in the species was also revealed in which more isolates of A. novoguineensis were encountered and their secondary metabolite profiles were examined using analytical HPLC with diode array and mass spectrometric detection (HPLC-DAD/MS). Remarkably, all isolated compounds are specifically produced by A. novoguineensis. |
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Geographical breakdown
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Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 27 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 19% |
Student > Bachelor | 4 | 15% |
Researcher | 3 | 11% |
Student > Doctoral Student | 2 | 7% |
Student > Postgraduate | 2 | 7% |
Other | 6 | 22% |
Unknown | 5 | 19% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 4 | 15% |
Chemistry | 4 | 15% |
Business, Management and Accounting | 1 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Other | 0 | 0% |
Unknown | 6 | 22% |