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An Expanded View of Complex Traits: From Polygenic to Omnigenic

Overview of attention for article published in Cell, June 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Citations

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1544 Dimensions

Readers on

mendeley
2910 Mendeley
citeulike
18 CiteULike
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Title
An Expanded View of Complex Traits: From Polygenic to Omnigenic
Published in
Cell, June 2017
DOI 10.1016/j.cell.2017.05.038
Pubmed ID
Authors

Evan A. Boyle, Yang I. Li, Jonathan K. Pritchard

Abstract

A central goal of genetics is to understand the links between genetic variation and disease. Intuitively, one might expect disease-causing variants to cluster into key pathways that drive disease etiology. But for complex traits, association signals tend to be spread across most of the genome-including near many genes without an obvious connection to disease. We propose that gene regulatory networks are sufficiently interconnected such that all genes expressed in disease-relevant cells are liable to affect the functions of core disease-related genes and that most heritability can be explained by effects on genes outside core pathways. We refer to this hypothesis as an "omnigenic" model.

Twitter Demographics

The data shown below were collected from the profiles of 822 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 2,910 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 14 <1%
United Kingdom 4 <1%
Spain 3 <1%
Sweden 2 <1%
Italy 2 <1%
Netherlands 1 <1%
Norway 1 <1%
Hong Kong 1 <1%
France 1 <1%
Other 9 <1%
Unknown 2872 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 751 26%
Researcher 620 21%
Student > Master 305 10%
Student > Bachelor 268 9%
Other 147 5%
Other 479 16%
Unknown 340 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 892 31%
Biochemistry, Genetics and Molecular Biology 816 28%
Medicine and Dentistry 186 6%
Neuroscience 122 4%
Computer Science 98 3%
Other 326 11%
Unknown 470 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 809. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 November 2021.
All research outputs
#14,339
of 19,499,600 outputs
Outputs from Cell
#125
of 15,987 outputs
Outputs of similar age
#343
of 283,998 outputs
Outputs of similar age from Cell
#5
of 135 outputs
Altmetric has tracked 19,499,600 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,987 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 46.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 283,998 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 135 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.