Title |
Anti-idiotypic antibodies reduce efficacy of the attenuated vaccine against highly pathogenic PRRSV challenge
|
---|---|
Published in |
BMC Veterinary Research, February 2014
|
DOI | 10.1186/1746-6148-10-39 |
Pubmed ID | |
Authors |
Ying Yu, Xuehui Cai, Gang Wang, Ning Kong, Yonggang Liu, Yihong Xiao, Chong Zhang, Yang Mu, Shuqi Xiao, Qin Zhao, Chengbao Wang, Gaiping Zhang, Julian A Hiscox, En-Min Zhou |
Abstract |
The inability of current vaccines to provide effective protection against porcine reproductive and respiratory syndrome virus (PRRSV) infection is not fully understood. One of the reasons might be the presence of anti-idiotypic antibodies (Ab2s) to the envelope glycoprotein GP5 induced by PRRSV infection since our previous studies demonstrated the presence of auto-Ab2s (aAb2s) in pigs infected with PRRSV. To test this hypothesis, PRRSV negative piglets were injected with a monoclonal Ab2 (Mab2-5G2) and aAb2s that are specific for anti-GP5 antibody, vaccinated with the attenuated PRRSV vaccine CH-1R and then challenged with the highly pathogenic PRRSV HuN4 strain. The animals were evaluated for clinical signs, pathological changes of the thymus and lungs, viremia, levels of serum antibodies and cytokines. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Mexico | 1 | 4% |
United States | 1 | 4% |
Unknown | 26 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 6 | 21% |
Researcher | 5 | 18% |
Professor | 3 | 11% |
Student > Bachelor | 2 | 7% |
Professor > Associate Professor | 2 | 7% |
Other | 5 | 18% |
Unknown | 5 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 9 | 32% |
Agricultural and Biological Sciences | 5 | 18% |
Engineering | 2 | 7% |
Medicine and Dentistry | 2 | 7% |
Computer Science | 1 | 4% |
Other | 3 | 11% |
Unknown | 6 | 21% |