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G Protein-Coupled Receptors in Drug Discovery

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Cover of 'G Protein-Coupled Receptors in Drug Discovery'

Table of Contents

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    Book Overview
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    Chapter 1 New Insights into GPCR Function: Implications for HTS
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    Chapter 2 Screening Technologies for G Protein-Coupled Receptors: From HTS to uHTS
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    Chapter 3 GPCR Signaling: Understanding the Pathway to Successful Drug Discovery
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    Chapter 4 An overview on GPCRs and drug discovery: structure-based drug design and structural biology on GPCRs.
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    Chapter 5 Understanding the Ligand–Receptor–G Protein Ternary Complex for GPCR Drug Discovery
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    Chapter 6 Assay Data Quality Assessment
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    Chapter 7 Homology Modeling of GPCRs
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    Chapter 8 GPCR Expression Using Baculovirus-Infected Sf9 Cells
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    Chapter 9 Radioligand Binding Assays: Application of [125I]Angiotensin II Receptor Binding
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    Chapter 10 G Protein-Coupled Receptors in Drug Discovery
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    Chapter 11 A Time-Resolved Fluorescent Lanthanide (Eu)-GTP Binding Assay for Chemokine Receptors as Targets in Drug Discovery
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    Chapter 12 Use of the DiscoveRx Hithunter cAMPII Assay for Direct Measurement of cAMP in Gs and Gi GPCRs
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    Chapter 13 Use of Aequorin for G protein-Coupled Receptor Hit Identification and Compound Profiling
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    Chapter 14 BacMam: versatile gene delivery technology for GPCR assays.
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    Chapter 15 Yeast Assays for G Protein-Coupled Receptors
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    Chapter 16 GPCR Microspot Assays on Solid Substrates
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    Chapter 17 Resonant Waveguide Grating Biosensor for Whole-Cell GPCR Assays
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    Chapter 18 FRET-Based Measurement of GPCR Conformational Changes
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    Chapter 19 FLIPR® Assays of Intracellular Calcium in GPCR Drug Discovery
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    Chapter 20 Use of Fluorescence Indicators in Receptor Ligands
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    Chapter 21 Application of Fluorescence Resonance Energy Transfer Techniques to Establish Ligand–Receptor Orientation
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    Chapter 22 G Protein-Coupled Receptors in Drug Discovery
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    Chapter 23 Using Reporter Gene Technologies to Detect Changes in cAMP as a Result of GPCR Activation
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    Chapter 24 A Quantum Dot-Labeled Ligand–Receptor Binding Assay for G Protein-Coupled Receptors Contained in Minimally Purified Membrane Nanopatches
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    Chapter 25 Xenopus Oocyte Electrophysiology in GPCR Drug Discovery
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    Chapter 26 Immunoprecipitation and Phosphorylation of G Protein-Coupled Receptors
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G Protein-Coupled Receptors in Drug Discovery
Published by
Humana Press, January 2009
DOI 10.1007/978-1-60327-317-6
978-1-60327-316-9, 978-1-60327-317-6

Leifert, Wayne R


Wayne R. Leifert

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The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 26%
Student > Ph. D. Student 3 16%
Researcher 2 11%
Student > Master 2 11%
Other 1 5%
Other 2 11%
Unknown 4 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 26%
Pharmacology, Toxicology and Pharmaceutical Science 4 21%
Agricultural and Biological Sciences 2 11%
Neuroscience 1 5%
Chemistry 1 5%
Other 1 5%
Unknown 5 26%