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Adipose tissue-derived stromal vascular fraction in regenerative medicine: a brief review on biology and translation

Overview of attention for article published in Stem Cell Research & Therapy, June 2017
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  • Above-average Attention Score compared to outputs of the same age and source (56th percentile)

Mentioned by

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3 tweeters
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1 Facebook page

Citations

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83 Dimensions

Readers on

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235 Mendeley
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Title
Adipose tissue-derived stromal vascular fraction in regenerative medicine: a brief review on biology and translation
Published in
Stem Cell Research & Therapy, June 2017
DOI 10.1186/s13287-017-0598-y
Pubmed ID
Authors

Pablo Bora, Anish S. Majumdar

Abstract

Adipose/fat tissue provides an abundant source of stromal vascular fraction (SVF) cells for immediate administration and can also give rise to a substantial number of cultured, multipotent adipose-derived stromal cells (ADSCs). Recently, both SVF and ADSCs have gained wide-ranging translational significance in regenerative medicine. Initially used for cosmetic breast enhancement, this mode of treatment has found use in many diseases involving immune disorders, tissue degeneration, and ischaemic conditions. In this review, we try to address several important aspects of this field, outlining the biology, technology, translation, and challenges related to SVF- and ADSC-based therapies. Starting from the basics of SVF and ADSC isolation, we touch upon recently developed technologies, addressing elements of novel methods and devices under development for point-of-care isolation of SVF. Characterisation of SVF cells and ADSCs is also an evolving area and we look into unusual expression of CD34 antigen as an interesting marker for such purposes. Based on reports involving different cells of the SVF, we draw a potential mode of action, focussing on angiogenesis since it involves multiple cells, unlike immunomodulation which is governed predominantly by ADSCs. We have looked into the latest research, experimental therapies, and clinical trials which are utilising SVF/ADSCs in conditions such as multiple sclerosis, Crohn's disease, peripheral neuropathy, osteoarthritis, diabetic foot ulcer, and so forth. However, problems have arisen with regards to the lack of proper regulatory guidelines for such therapies and, since the introduction of US Food and Drug Administration draft guidelines and the Reliable and Effective Growth for Regenerative Health Options that Improve Wellness (REGROW) Act, the debate became more public with regards to safe and efficacious use of these cells.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 235 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 235 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 37 16%
Student > Ph. D. Student 32 14%
Student > Bachelor 29 12%
Student > Master 26 11%
Student > Doctoral Student 21 9%
Other 44 19%
Unknown 46 20%
Readers by discipline Count As %
Medicine and Dentistry 74 31%
Biochemistry, Genetics and Molecular Biology 43 18%
Agricultural and Biological Sciences 27 11%
Immunology and Microbiology 7 3%
Engineering 5 2%
Other 23 10%
Unknown 56 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 March 2018.
All research outputs
#7,335,782
of 12,719,839 outputs
Outputs from Stem Cell Research & Therapy
#527
of 1,086 outputs
Outputs of similar age
#129,560
of 266,240 outputs
Outputs of similar age from Stem Cell Research & Therapy
#19
of 46 outputs
Altmetric has tracked 12,719,839 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,086 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,240 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.