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FGF23 promotes renal calcium reabsorption through the TRPV5 channel

Overview of attention for article published in EMBO Journal, February 2014
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

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1 Mendeley
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Title
FGF23 promotes renal calcium reabsorption through the TRPV5 channel
Published in
EMBO Journal, February 2014
DOI 10.1002/embj.201284188
Pubmed ID
Authors

Olena Andrukhova, Alina Smorodchenko, Monika Egerbacher, Carmen Streicher, Ute Zeitz, Regina Goetz, Victoria Shalhoub, Moosa Mohammadi, Elena E Pohl, Beate Lanske, Reinhold G Erben, Andrukhova O, Smorodchenko A, Egerbacher M, Streicher C, Zeitz U, Goetz R, Shalhoub V, Mohammadi M, Pohl EE, Lanske B, Erben RG

Abstract

αKlotho is thought to activate the epithelial calcium channel Transient Receptor Potential Vanilloid-5 (TRPV5) in distal renal tubules through its putative glucuronidase/sialidase activity, thereby preventing renal calcium loss. However, αKlotho also functions as the obligatory co-receptor for fibroblast growth factor-23 (FGF23), a bone-derived phosphaturic hormone. Here, we show that renal calcium reabsorption and renal membrane abundance of TRPV5 are reduced in Fgf23 knockout mice, similar to what is seen in αKlotho knockout mice. We further demonstrate that αKlotho neither co-localizes with TRPV5 nor is regulated by FGF23. Rather, apical membrane abundance of TRPV5 in renal distal tubules and thus renal calcium reabsorption are regulated by FGF23, which binds the FGF receptor-αKlotho complex and activates a signaling cascade involving ERK1/2, SGK1, and WNK4. Our data thereby identify FGF23, not αKlotho, as a calcium-conserving hormone in the kidney.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 1 Mendeley reader of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 100%
United Kingdom 1 100%
Netherlands 1 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 1100%
Student > Ph. D. Student 9 900%
Professor > Associate Professor 8 800%
Student > Bachelor 5 500%
Professor 4 400%
Other 15 1500%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 1900%
Medicine and Dentistry 17 1700%
Unspecified 6 600%
Biochemistry, Genetics and Molecular Biology 6 600%
Veterinary Science and Veterinary Medicine 1 100%
Other 3 300%

Attention Score in Context

This research output has an Altmetric Attention Score of 34. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2015.
All research outputs
#188,134
of 6,577,121 outputs
Outputs from EMBO Journal
#71
of 4,171 outputs
Outputs of similar age
#7,134
of 168,093 outputs
Outputs of similar age from EMBO Journal
#6
of 37 outputs
Altmetric has tracked 6,577,121 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,171 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 168,093 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.