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Gum Arabic as fetal hemoglobin inducing agent in sickle cell anemia; in vivo study

Overview of attention for article published in BMC Hematology, December 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)

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Title
Gum Arabic as fetal hemoglobin inducing agent in sickle cell anemia; in vivo study
Published in
BMC Hematology, December 2015
DOI 10.1186/s12878-015-0040-6
Pubmed ID
Authors

Lamis Kaddam, Imad FdleAlmula, Omer Ali Eisawi, Haydar Awad Abdelrazig, Mustafa Elnimeiri, Florian Lang, Amal M. Saeed

Abstract

High levels of fetal haemoglobin (HbF) decrease sickle cell anaemia (SCA) severity and leads to improved survival. According to in vivo and in vitro studies, butyrate increases HbF production. Its utilization in clinical practice is hampered, however, by its short half-life. Serum butyrate concentrations could be enhanced by colonic bacterial fermentation of Gum Arabic (GA), edible, dried, gummy exudates from Acacia Senegal tree. We hypothesized that regular intake of GA increases serum butyrate levels, thus inducing HbF production and ameliorating symptoms of sickle cell anemia. Fourty seven patients (5-42 years) carrying hemoglobin SS were recruited from April 2014 to January 2015. Patients received 30 g/day GA for 12 weeks. HbF, blood count and erythropoietin level were measured. The main outcome of interest was the level of HbF after 12 weeks. The secondary outcomes were improvement in clinical and laboratory results. The study was ethically approved by Alneelain University IRB. The study revealed significant increase in HbF level P.V0.000 [95 % CI, 0.43-1.02], MCV P.V:000 [95 % CI, 2.312-6.058] and Hematocrit level P.V:0.026 [95 % CI, 0.124-1.902]. No significant difference was encountered in platelets count P.V: 0.346 [95 % CI,-25.76-71.94], and WBCs count P.V:0.194 [95 % CI,-8.035-1.68]. Thirty seven percent of patients experienced minor side effects which resolved within a week. These findings reveal a novel effect of GA, which may be used to foster fetal hemoglobin production. ClinicalTrials.gov Identifier: NCT02467257. Registered 3rd June 2015.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 39%
Student > Ph. D. Student 3 17%
Researcher 2 11%
Professor 1 6%
Professor > Associate Professor 1 6%
Other 1 6%
Unknown 3 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 28%
Medicine and Dentistry 4 22%
Immunology and Microbiology 2 11%
Social Sciences 2 11%
Nursing and Health Professions 1 6%
Other 1 6%
Unknown 3 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2017.
All research outputs
#1,081,988
of 11,383,682 outputs
Outputs from BMC Hematology
#4
of 74 outputs
Outputs of similar age
#43,257
of 263,502 outputs
Outputs of similar age from BMC Hematology
#1
of 1 outputs
Altmetric has tracked 11,383,682 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 74 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,502 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them