Title |
Human protein Staufen-2 promotes HIV-1 proliferation by positively regulating RNA export activity of viral protein Rev
|
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Published in |
Retrovirology, February 2014
|
DOI | 10.1186/1742-4690-11-18 |
Pubmed ID | |
Authors |
Atoshi Banerjee, Ronald Benjamin, Kannan Balakrishnan, Payel Ghosh, Sharmistha Banerjee |
Abstract |
The export of intron containing viral RNAs from the nucleus to the cytoplasm is an essential step in the life cycle of Human Immunodeficiency Virus-1 (HIV-1). As the eukaryotic system does not permit the transport of intron containing RNA out of the nucleus, HIV-1 makes a regulatory protein, Rev, that mediates the transportation of unspliced and partially spliced viral mRNA from the nucleus to the cytoplasm, thereby playing a decisive role in the generation of new infectious virus particles. Therefore, the host factors modulating the RNA export activity of Rev can be major determinants of virus production in an infected cell. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 3% |
United States | 1 | 3% |
Unknown | 37 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 18% |
Student > Ph. D. Student | 7 | 18% |
Student > Doctoral Student | 3 | 8% |
Student > Master | 3 | 8% |
Other | 2 | 5% |
Other | 3 | 8% |
Unknown | 14 | 36% |
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Biochemistry, Genetics and Molecular Biology | 7 | 18% |
Immunology and Microbiology | 6 | 15% |
Medicine and Dentistry | 4 | 10% |
Agricultural and Biological Sciences | 4 | 10% |
Unspecified | 1 | 3% |
Other | 3 | 8% |
Unknown | 14 | 36% |