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Milk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy?

Overview of attention for article published in Journal of Translational Medicine, January 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

blogs
1 blog
twitter
3 tweeters
patent
1 patent
reddit
2 Redditors

Citations

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78 Dimensions

Readers on

mendeley
122 Mendeley
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Title
Milk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy?
Published in
Journal of Translational Medicine, January 2014
DOI 10.1186/1479-5876-12-43
Pubmed ID
Authors

Bodo C Melnik, Swen John, Gerd Schmitz

Abstract

Epidemiological evidence confirmed that raw cow's milk consumption in the first year of life protects against the development of atopic diseases and increases the number of regulatory T-cells (Tregs). However, milk's atopy-protective mode of action remains elusive.This review supported by translational research proposes that milk-derived microRNAs (miRs) may represent the missing candidates that promote long-term lineage commitment of Tregs downregulating IL-4/Th2-mediated atopic sensitization and effector immune responses. Milk transfers exosomal miRs including the ancient miR-155, which is important for the development of the immune system and controls pivotal target genes involved in the regulation of FoxP3 expression, IL-4 signaling, immunoglobulin class switching to IgE and FcϵRI expression. Boiling of milk abolishes milk's exosomal miR-mediated bioactivity. Infant formula in comparison to human breast- or cow's milk is deficient in bioactive exosomal miRs that may impair FoxP3 expression. The boost of milk-mediated miR may induce pivotal immunoregulatory and epigenetic modifications required for long-term thymic Treg lineage commitment explaining the atopy-protective effect of raw cow's milk consumption.The presented concept offers a new option for the prevention of atopic diseases by the addition of physiological amounts of miR-155-enriched exosomes to infant formula for mothers incapable of breastfeeding.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 122 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 <1%
Russia 1 <1%
Brazil 1 <1%
Unknown 119 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 36 30%
Student > Ph. D. Student 26 21%
Student > Master 13 11%
Student > Bachelor 9 7%
Professor 7 6%
Other 17 14%
Unknown 14 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 44 36%
Medicine and Dentistry 23 19%
Biochemistry, Genetics and Molecular Biology 13 11%
Pharmacology, Toxicology and Pharmaceutical Science 4 3%
Neuroscience 3 2%
Other 15 12%
Unknown 20 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 June 2019.
All research outputs
#1,185,743
of 15,323,046 outputs
Outputs from Journal of Translational Medicine
#174
of 2,885 outputs
Outputs of similar age
#20,645
of 257,274 outputs
Outputs of similar age from Journal of Translational Medicine
#8
of 210 outputs
Altmetric has tracked 15,323,046 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,885 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 257,274 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 210 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.