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Milk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy?

Overview of attention for article published in Journal of Translational Medicine, January 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

blogs
1 blog
twitter
3 tweeters
patent
1 patent
reddit
2 Redditors

Citations

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110 Dimensions

Readers on

mendeley
156 Mendeley
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Title
Milk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy?
Published in
Journal of Translational Medicine, January 2014
DOI 10.1186/1479-5876-12-43
Pubmed ID
Authors

Bodo C Melnik, Swen John, Gerd Schmitz

Abstract

Epidemiological evidence confirmed that raw cow's milk consumption in the first year of life protects against the development of atopic diseases and increases the number of regulatory T-cells (Tregs). However, milk's atopy-protective mode of action remains elusive.This review supported by translational research proposes that milk-derived microRNAs (miRs) may represent the missing candidates that promote long-term lineage commitment of Tregs downregulating IL-4/Th2-mediated atopic sensitization and effector immune responses. Milk transfers exosomal miRs including the ancient miR-155, which is important for the development of the immune system and controls pivotal target genes involved in the regulation of FoxP3 expression, IL-4 signaling, immunoglobulin class switching to IgE and FcϵRI expression. Boiling of milk abolishes milk's exosomal miR-mediated bioactivity. Infant formula in comparison to human breast- or cow's milk is deficient in bioactive exosomal miRs that may impair FoxP3 expression. The boost of milk-mediated miR may induce pivotal immunoregulatory and epigenetic modifications required for long-term thymic Treg lineage commitment explaining the atopy-protective effect of raw cow's milk consumption.The presented concept offers a new option for the prevention of atopic diseases by the addition of physiological amounts of miR-155-enriched exosomes to infant formula for mothers incapable of breastfeeding.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 156 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 <1%
Unknown 155 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 41 26%
Student > Ph. D. Student 32 21%
Student > Master 15 10%
Student > Bachelor 13 8%
Student > Doctoral Student 8 5%
Other 22 14%
Unknown 25 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 50 32%
Medicine and Dentistry 26 17%
Biochemistry, Genetics and Molecular Biology 22 14%
Pharmacology, Toxicology and Pharmaceutical Science 4 3%
Nursing and Health Professions 3 2%
Other 18 12%
Unknown 33 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 May 2021.
All research outputs
#1,762,390
of 21,363,193 outputs
Outputs from Journal of Translational Medicine
#276
of 3,689 outputs
Outputs of similar age
#23,000
of 290,652 outputs
Outputs of similar age from Journal of Translational Medicine
#7
of 67 outputs
Altmetric has tracked 21,363,193 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,689 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.0. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 290,652 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.