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Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer’s disease

Overview of attention for article published in Acta Neuropathologica Communications, February 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

twitter
2 tweeters
wikipedia
1 Wikipedia page

Citations

dimensions_citation
13 Dimensions

Readers on

mendeley
58 Mendeley
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Title
Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer’s disease
Published in
Acta Neuropathologica Communications, February 2014
DOI 10.1186/2051-5960-2-17
Pubmed ID
Authors

Sonia George, Annica Rönnbäck, Gunnar K Gouras, Géraldine H Petit, Fiona Grueninger, Bengt Winblad, Caroline Graff, Patrik Brundin

Abstract

The progressive development of Alzheimer's disease (AD) pathology follows a spatiotemporal pattern in the human brain. In a transgenic (Tg) mouse model of AD expressing amyloid precursor protein (APP) with the arctic (E693G) mutation, pathology spreads along anatomically connected structures. Amyloid-β (Aβ) pathology first appears in the subiculum and is later detected in interconnected brain regions, including the retrosplenial cortex. We investigated whether the spatiotemporal pattern of Aβ pathology in the Tg APP arctic mice to interconnected brain structures can be interrupted by destroying neurons using a neurotoxin and thereby disconnecting the neural circuitry.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Netherlands 1 2%
Unknown 56 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 28%
Student > Ph. D. Student 9 16%
Student > Master 9 16%
Professor 7 12%
Student > Bachelor 4 7%
Other 7 12%
Unknown 6 10%
Readers by discipline Count As %
Neuroscience 17 29%
Agricultural and Biological Sciences 15 26%
Medicine and Dentistry 5 9%
Biochemistry, Genetics and Molecular Biology 3 5%
Psychology 3 5%
Other 6 10%
Unknown 9 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2014.
All research outputs
#1,020,095
of 5,037,615 outputs
Outputs from Acta Neuropathologica Communications
#93
of 242 outputs
Outputs of similar age
#32,138
of 143,438 outputs
Outputs of similar age from Acta Neuropathologica Communications
#4
of 27 outputs
Altmetric has tracked 5,037,615 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 242 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 143,438 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.