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Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach

Overview of attention for article published in Nature Communications, February 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
26 news outlets
blogs
2 blogs
twitter
7 tweeters
patent
1 patent

Citations

dimensions_citation
143 Dimensions

Readers on

mendeley
247 Mendeley
citeulike
1 CiteULike
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Title
Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach
Published in
Nature Communications, February 2014
DOI 10.1038/ncomms4277
Pubmed ID
Authors

Jason T. Weiss, John C. Dawson, Kenneth G. Macleod, Witold Rybski, Craig Fraser, Carmen Torres-Sánchez, E. Elizabeth Patton, Mark Bradley, Neil O. Carragher, Asier Unciti-Broceta, Weiss JT, Dawson JC, Macleod KG, Rybski W, Fraser C, Torres-Sánchez C, Patton EE, Bradley M, Carragher NO, Unciti-Broceta A

Abstract

A bioorthogonal organometallic reaction is a biocompatible transformation undergone by a synthetic material exclusively through the mediation of a non-biotic metal source; a selective process used to label biomolecules and activate probes in biological environs. Here we report the in vitro bioorthogonal generation of 5-fluorouracil from a biologically inert precursor by heterogeneous Pd(0) catalysis. Although independently harmless, combined treatment of 5-fluoro-1-propargyl-uracil and Pd(0)-functionalized resins exhibits comparable antiproliferative properties to the unmodified drug in colorectal and pancreatic cancer cells. Live-cell imaging and immunoassay studies demonstrate that the cytotoxic activity of the prodrug/Pd(0)-resin combination is due to the in situ generation of 5-fluorouracil. Pd(0)-resins can be carefully implanted in the yolk sac of zebrafish embryos and display excellent biocompatibility and local catalytic activity. The in vitro efficacy shown by this masking/activation strategy underlines its potential to develop a bioorthogonally activated prodrug approach and supports further in vivo investigations.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 247 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 2 <1%
Germany 1 <1%
Brazil 1 <1%
United Kingdom 1 <1%
China 1 <1%
United States 1 <1%
Unknown 240 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 60 24%
Researcher 45 18%
Student > Master 29 12%
Student > Bachelor 27 11%
Other 26 11%
Other 40 16%
Unknown 20 8%
Readers by discipline Count As %
Chemistry 133 54%
Agricultural and Biological Sciences 45 18%
Biochemistry, Genetics and Molecular Biology 10 4%
Chemical Engineering 6 2%
Pharmacology, Toxicology and Pharmaceutical Science 5 2%
Other 25 10%
Unknown 23 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 206. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 July 2018.
All research outputs
#100,417
of 17,353,889 outputs
Outputs from Nature Communications
#1,437
of 34,109 outputs
Outputs of similar age
#1,260
of 266,478 outputs
Outputs of similar age from Nature Communications
#2
of 221 outputs
Altmetric has tracked 17,353,889 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 34,109 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 51.9. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,478 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 221 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.