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The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation

Overview of attention for article published in Nucleic Acids Research, June 2017
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

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16 tweeters

Citations

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5 Dimensions

Readers on

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31 Mendeley
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Title
The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation
Published in
Nucleic Acids Research, June 2017
DOI 10.1093/nar/gkx529
Pubmed ID
Authors

Fernando Gómez-Herreros, Thanasis Margaritis, Olga Rodríguez-Galán, Vicent Pelechano, Victoria Begley, Gonzalo Millán-Zambrano, Macarena Morillo-Huesca, Mari Cruz Muñoz-Centeno, José E. Pérez-Ortín, Jesús de la Cruz, Frank C. P. Holstege, Sebastián Chávez

Abstract

Ribosome assembly requires the concerted expression of hundreds of genes, which are transcribed by all three nuclear RNA polymerases. Transcription elongation involves dynamic interactions between RNA polymerases and chromatin. We performed a synthetic lethal screening in Saccharomyces cerevisiae with a conditional allele of SPT6, which encodes one of the factors that facilitates this process. Some of these synthetic mutants corresponded to factors that facilitate pre-rRNA processing and ribosome biogenesis. We found that the in vivo depletion of one of these factors, Arb1, activated transcription elongation in the set of genes involved directly in ribosome assembly. Under these depletion conditions, Spt6 was physically targeted to the up-regulated genes, where it helped maintain their chromatin integrity and the synthesis of properly stable mRNAs. The mRNA profiles of a large set of ribosome biogenesis mutants confirmed the existence of a feedback regulatory network among ribosome assembly genes. The transcriptional response in this network depended on both the specific malfunction and the role of the regulated gene. In accordance with our screening, Spt6 positively contributed to the optimal operation of this global network. On the whole, this work uncovers a feedback control of ribosome biogenesis by fine-tuning transcription elongation in ribosome assembly factor-coding genes.

Twitter Demographics

The data shown below were collected from the profiles of 16 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 32%
Researcher 8 26%
Professor 3 10%
Student > Master 3 10%
Student > Bachelor 2 6%
Other 5 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 58%
Biochemistry, Genetics and Molecular Biology 8 26%
Immunology and Microbiology 2 6%
Veterinary Science and Veterinary Medicine 1 3%
Medicine and Dentistry 1 3%
Other 1 3%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 July 2018.
All research outputs
#1,946,430
of 13,664,802 outputs
Outputs from Nucleic Acids Research
#3,559
of 21,430 outputs
Outputs of similar age
#52,739
of 264,204 outputs
Outputs of similar age from Nucleic Acids Research
#58
of 317 outputs
Altmetric has tracked 13,664,802 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 21,430 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,204 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 317 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.