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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss
|
|---|---|
| Published in |
Nature Communications, June 2017
|
| DOI | 10.1038/ncomms15613 |
| Pubmed ID | |
| Authors |
Marco Quarta, Melinda Cromie, Robert Chacon, Justin Blonigan, Victor Garcia, Igor Akimenko, Mark Hamer, Patrick Paine, Merel Stok, Joseph B. Shrager, Thomas A. Rando |
| Abstract |
Volumetric muscle loss (VML) is associated with loss of skeletal muscle function, and current treatments show limited efficacy. Here we show that bioconstructs suffused with genetically-labelled muscle stem cells (MuSCs) and other muscle resident cells (MRCs) are effective to treat VML injuries in mice. Imaging of bioconstructs implanted in damaged muscles indicates MuSCs survival and growth, and ex vivo analyses show force restoration of treated muscles. Histological analysis highlights myofibre formation, neovascularisation, but insufficient innervation. Both innervation and in vivo force production are enhanced when implantation of bioconstructs is followed by an exercise regimen. Significant improvements are also observed when bioconstructs are used to treat chronic VML injury models. Finally, we demonstrate that bioconstructs made with human MuSCs and MRCs can generate functional muscle tissue in our VML model. These data suggest that stem cell-based therapies aimed to engineer tissue in vivo may be effective to treat acute and chronic VML. |
X Demographics
The data shown below were collected from the profiles of 28 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 18% |
| United Kingdom | 3 | 11% |
| Japan | 2 | 7% |
| Australia | 2 | 7% |
| Ecuador | 1 | 4% |
| France | 1 | 4% |
| Canada | 1 | 4% |
| Norway | 1 | 4% |
| Unknown | 12 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 16 | 57% |
| Scientists | 9 | 32% |
| Science communicators (journalists, bloggers, editors) | 3 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 268 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 268 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 51 | 19% |
| Student > Master | 35 | 13% |
| Student > Bachelor | 35 | 13% |
| Researcher | 27 | 10% |
| Student > Doctoral Student | 23 | 9% |
| Other | 38 | 14% |
| Unknown | 59 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 51 | 19% |
| Engineering | 46 | 17% |
| Agricultural and Biological Sciences | 30 | 11% |
| Medicine and Dentistry | 25 | 9% |
| Materials Science | 7 | 3% |
| Other | 33 | 12% |
| Unknown | 76 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2022.
All research outputs
#1,587,122
of 23,630,563 outputs
Outputs from Nature Communications
#21,470
of 49,253 outputs
Outputs of similar age
#32,714
of 317,760 outputs
Outputs of similar age from Nature Communications
#543
of 1,095 outputs
Altmetric has tracked 23,630,563 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 49,253 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.2. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,760 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 1,095 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.