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Screening and characterization of lactic acid bacterial strains that produce fermented milk and reduce cholesterol levels

Overview of attention for article published in Brazilian Journal of Microbiology, October 2017
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Title
Screening and characterization of lactic acid bacterial strains that produce fermented milk and reduce cholesterol levels
Published in
Brazilian Journal of Microbiology, October 2017
DOI 10.1016/j.bjm.2017.02.011
Pubmed ID
Authors

Xuefang Guan, Qingxian Xu, Yi Zheng, Lei Qian, Bin Lin

Abstract

To screen for and characterize lactic acid bacteria strains with the ability to produce fermented milk and reduce cholesterol levels. The strains were isolated from traditional fermented milk in China. In vitro and in vivo evaluation of cholesterol-reduction were used to identify and verify strains of interest. Characteristics were analyzed using spectrophotometry and plate counting assays. The isolate HLX37 consistently produced fermented milk with strong cholesterol-reducing properties was identified as Lactobacillus plantarum (accession number: KR105940) and was thus selected for further study. The cholesterol reduction by strain HLX37 was 45.84%. The isolates were acid-tolerant at pH 2.5 and bile-tolerant at 0.5% (w/v) in simulated gastric juice (pH 2.5) for 2h and in simulated intestinal fluid (pH 8.0) for 3h. The auto-aggregation rate increased to 87.74% after 24h, while the co-aggregation with Escherichia coli DH5 was 27.76%. Strain HLX37 was intrinsically resistant to antibiotics such as penicillin, tobramycin, kanamycin, streptomycin, vancomycin and amikacin. Compared with rats in the model hyperlipidemia group, the total cholesterol content in the serum and the liver as well as the atherogenic index of rats in the viable fermented milk group significantly decreased by 23.33%, 32.37% and 40.23%, respectively. Fewer fat vacuoles and other lesions in liver tissue were present in both the inactivated and viable fermented milk groups compared to the model group. These studies indicate that strain HLX37 of L. plantarum demonstrates probiotic potential, potential for use as a candidate for commercial use for promoting health.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 71 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 15 21%
Student > Bachelor 9 13%
Student > Ph. D. Student 8 11%
Researcher 6 8%
Other 4 6%
Other 11 15%
Unknown 18 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 15%
Immunology and Microbiology 7 10%
Engineering 6 8%
Biochemistry, Genetics and Molecular Biology 6 8%
Medicine and Dentistry 3 4%
Other 12 17%
Unknown 26 37%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2017.
All research outputs
#9,893,140
of 12,355,257 outputs
Outputs from Brazilian Journal of Microbiology
#276
of 363 outputs
Outputs of similar age
#194,241
of 267,582 outputs
Outputs of similar age from Brazilian Journal of Microbiology
#24
of 37 outputs
Altmetric has tracked 12,355,257 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 363 research outputs from this source. They receive a mean Attention Score of 2.2. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,582 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.