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Mesoporous silica-based dosage forms improve bioavailability of poorly soluble drugs in pigs: case example fenofibrate

Overview of attention for article published in Journal of Pharmacy & Pharmacology, June 2017
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  • Good Attention Score compared to outputs of the same age (69th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

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6 tweeters

Citations

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12 Dimensions

Readers on

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29 Mendeley
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Title
Mesoporous silica-based dosage forms improve bioavailability of poorly soluble drugs in pigs: case example fenofibrate
Published in
Journal of Pharmacy & Pharmacology, June 2017
DOI 10.1111/jphp.12767
Pubmed ID
Authors

Joseph P O'Shea, Kalpa Nagarsekar, Alena Wieber, Vanessa Witt, Elisabeth Herbert, Caitriona M O'Driscoll, Christoph Saal, Dieter Lubda, Brendan T Griffin, Jennifer B Dressman

Abstract

Mesoporous silicas (SLC) have demonstrated considerable potential to improve bioavailability of poorly soluble drugs by facilitating rapid dissolution and generating supersaturation. The addition of certain polymers can further enhance the dissolution of these formulations by preventing drug precipitation. This study uses fenofibrate as a model drug to investigate the performance of an SLC-based formulation, delivered with hydroxypropyl methylcellulose acetate succinate (HPMCAS) as a precipitation inhibitor, in pigs. The ability of biorelevant dissolution testing to predict the in vivo performance was also assessed. Fenofibrate-loaded mesoporous silica (FF-SLC), together with HPMCAS, displayed significant improvements in biorelevant dissolution tests relative to a reference formulation consisting of a physical mixture of crystalline fenofibrate with HPMCAS. In vivo assessment in fasted pigs demonstrated bioavailabilities of 86.69 ± 35.37% with combination of FF-SLC and HPMCAS in capsule form and 75.47 ± 14.58% as a suspension, compared to 19.92 ± 9.89% with the reference formulation. A positive correlation was identified between bioavailability and dissolution efficiency. The substantial improvements in bioavailability of fenofibrate from the SLC-based formulations confirm the ability of this formulation strategy to overcome the dissolution and solubility limitations, further raising the prospects of a future commercially available SLC-based formulation.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 14%
Student > Master 4 14%
Professor 3 10%
Unspecified 2 7%
Lecturer 2 7%
Other 4 14%
Unknown 10 34%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 9 31%
Unspecified 2 7%
Medicine and Dentistry 2 7%
Chemical Engineering 1 3%
Business, Management and Accounting 1 3%
Other 3 10%
Unknown 11 38%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 September 2017.
All research outputs
#4,526,304
of 16,956,273 outputs
Outputs from Journal of Pharmacy & Pharmacology
#553
of 2,611 outputs
Outputs of similar age
#82,280
of 273,614 outputs
Outputs of similar age from Journal of Pharmacy & Pharmacology
#3
of 14 outputs
Altmetric has tracked 16,956,273 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 2,611 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,614 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.