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High sensitivity non-invasive detection of calcifications deep inside biological tissue using Transmission Raman Spectroscopy

Overview of attention for article published in Journal of Biophotonics, June 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (57th percentile)
  • Good Attention Score compared to outputs of the same age and source (74th percentile)

Mentioned by

twitter
3 tweeters
facebook
1 Facebook page

Citations

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19 Dimensions

Readers on

mendeley
37 Mendeley
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Title
High sensitivity non-invasive detection of calcifications deep inside biological tissue using Transmission Raman Spectroscopy
Published in
Journal of Biophotonics, June 2017
DOI 10.1002/jbio.201600260
Pubmed ID
Authors

Adrian Ghita, Pavel Matousek, Nick Stone

Abstract

The aim of this research was to develop a novel approach to probe non-invasively the composition of inorganic chemicals buried deep in large volume biological samples. The method is based on advanced Transmission Raman Spectroscopy (TRS) permitting chemical specific detection within a large sampling volume. The approach could be beneficial to chemical identification of the breast calcifications detected during mammographic X-ray procedures. The chemical composition of a breast calcification reflects the pathology of the surrounding tissue, malignant or benign and potentially the grade of malignancy. However, this information is not available from mammography, leading to excisional biopsy and histopathological assessment for a definitive diagnosis. Here we present, for the first time, a design of a new high performance deep Raman instrument and demonstrate its capability to detect type II calcifications (calcium hydroxyapatite) at clinically relevant concentrations and depths of around 40 mm in phantom tissue. This is around double the penetration depth achieved with our previous instrument design and around two orders of magnitude higher than that possible when using conventional Raman spectroscopy.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 22%
Researcher 8 22%
Student > Master 6 16%
Other 2 5%
Student > Bachelor 2 5%
Other 4 11%
Unknown 7 19%
Readers by discipline Count As %
Engineering 5 14%
Chemistry 5 14%
Biochemistry, Genetics and Molecular Biology 4 11%
Medicine and Dentistry 4 11%
Physics and Astronomy 3 8%
Other 4 11%
Unknown 12 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2019.
All research outputs
#7,590,830
of 14,354,509 outputs
Outputs from Journal of Biophotonics
#391
of 1,441 outputs
Outputs of similar age
#111,258
of 266,378 outputs
Outputs of similar age from Journal of Biophotonics
#10
of 39 outputs
Altmetric has tracked 14,354,509 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,441 research outputs from this source. They receive a mean Attention Score of 3.1. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,378 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.