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D-2-Hydroxyglutarate producing neo-enzymatic activity inversely correlates with frequency of the type of isocitrate dehydrogenase 1 mutations found in glioma

Overview of attention for article published in Acta Neuropathologica Communications, February 2014
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Title
D-2-Hydroxyglutarate producing neo-enzymatic activity inversely correlates with frequency of the type of isocitrate dehydrogenase 1 mutations found in glioma
Published in
Acta Neuropathologica Communications, February 2014
DOI 10.1186/2051-5960-2-19
Pubmed ID
Authors

Stefan Pusch, Leonille Schweizer, Ann-Christin Beck, Johanna-Marie Lehmler, Susanne Weissert, Jörg Balss, Aubry K Miller, Andreas von Deimling

Abstract

IDH mutations frequently occur in diffuse gliomas and result in a neo-enzymatic activity that results in reduction of α-ketoglutarate to D-2-hydroxyglutarate. In gliomas, the frequency of IDH1 mutations in codon 132 increases in the order R132L-R132S-R132G-R132C-R132H with R132H constituting more than 90% of all IDH1 mutations.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Unknown 75 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 17 22%
Researcher 12 16%
Student > Bachelor 10 13%
Student > Ph. D. Student 8 10%
Student > Postgraduate 4 5%
Other 13 17%
Unknown 13 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 21 27%
Agricultural and Biological Sciences 18 23%
Medicine and Dentistry 10 13%
Neuroscience 6 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 4 5%
Unknown 16 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2014.
All research outputs
#18,365,132
of 22,745,803 outputs
Outputs from Acta Neuropathologica Communications
#1,228
of 1,369 outputs
Outputs of similar age
#234,493
of 314,263 outputs
Outputs of similar age from Acta Neuropathologica Communications
#27
of 41 outputs
Altmetric has tracked 22,745,803 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,369 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.8. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,263 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.