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Synthesis and evaluation of arylamidine derivatives for new antimicrobial and cytotoxic activities

Overview of attention for article published in Anais da Academia Brasileira de Ciências, June 2017
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  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

twitter
2 tweeters
facebook
1 Facebook page

Readers on

mendeley
8 Mendeley
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Title
Synthesis and evaluation of arylamidine derivatives for new antimicrobial and cytotoxic activities
Published in
Anais da Academia Brasileira de Ciências, June 2017
DOI 10.1590/0001-3765201720160801
Pubmed ID
Authors

ZENAIDE S. MONTE, AMANDA M. SILVA, GLÁUCIA M.S. LIMA, TERESINHA G. DA SILVA, KARLA M.R. MARQUES, MARIA D. RODRIGUES, EMERSON P.S. FALCÃO, SEBASTIÃO J. MELO

Abstract

A series of arylamidines 3a-j was designed, synthesized and investigated for antimicrobial activity. Structures of the compounds were confirmed by IR, 1H-NMR and 13C-NMR and a 2D spectroscopic study was performed. A preliminary screening of the antimicrobial tests clearly showed that three out of ten arylamidines, viz, 3f, 3g and 3i, were effective against all the gram-negative bacteria: Klebsiella pneumoniae, Pseudomonas aeruginosa and Salmonella enteric; and against the yeast, candida albicans. Further, the Minimum Inhibitory Concentrations (MIC) against the bacteria and yeast were determined. All compounds 3a-d, 3f, 3g, 3i and 3j were also investigated for their low cytotoxic effects on tested cell lines. Compounds 3d and 3f were the most effective derivatives against HL-60 and HEp-2 cells, respectively, with IC50 value (2µg/mL), and low normal cells toxicity.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 50%
Professor 1 13%
Student > Master 1 13%
Student > Doctoral Student 1 13%
Unknown 1 13%
Readers by discipline Count As %
Engineering 2 25%
Computer Science 1 13%
Agricultural and Biological Sciences 1 13%
Biochemistry, Genetics and Molecular Biology 1 13%
Medicine and Dentistry 1 13%
Other 2 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2021.
All research outputs
#11,126,344
of 18,666,194 outputs
Outputs from Anais da Academia Brasileira de Ciências
#151
of 251 outputs
Outputs of similar age
#138,339
of 277,799 outputs
Outputs of similar age from Anais da Academia Brasileira de Ciências
#2
of 5 outputs
Altmetric has tracked 18,666,194 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 251 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,799 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.