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Effects of liposomal-curcumin on five opportunistic bacterial strains found in the equine hindgut - preliminary study

Overview of attention for article published in Journal of Animal Science and Technology, June 2017
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  • Above-average Attention Score compared to outputs of the same age (51st percentile)

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4 tweeters
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2 Facebook pages

Citations

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3 Dimensions

Readers on

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27 Mendeley
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Title
Effects of liposomal-curcumin on five opportunistic bacterial strains found in the equine hindgut - preliminary study
Published in
Journal of Animal Science and Technology, June 2017
DOI 10.1186/s40781-017-0138-4
Pubmed ID
Authors

S. D. Bland, E. B. Venable, J. L. McPherson, R. L. Atkinson

Abstract

The horse intestinal tract is sensitive and contains a highly complex microbial population. A shift in the microbial population can lead to various issues such as inflammation and colic. The use of nutraceuticals in the equine industry is on the rise and curcumin is thought to possess antimicrobial properties that may help to minimize the proliferation of opportunistic bacteria. Four cecally-cannulated horses were utilized to determine the optimal dose of liposomal-curcumin (LIPC) on reducing Streptococcus bovis/equinus complex (SBEC), Escherichia coli K-12, Escherichia coli general, Clostridium difficile, and Clostridium perfringens in the equine hindgut without adversely affecting cecal characteristics. In the first study cecal fluid was collected from each horse and composited for an in vitro, 24 h batch culture to examine LIPC at four different dosages (15, 20, 25, and 30 g) in a completely randomized design. A subsequent in vivo 4 × 4 Latin square design study was conducted to evaluate no LIPC (control, CON) or LIPC dosed at 15, 25, and 35 g per day (dosages determined from in vitro results) for 9 days on the efficacy of LIPC on selected bacterial strains, pH, and volatile fatty acids. Each period was 14 days with 9 d for acclimation and 5 d withdrawal period. In the in vitro study dosage had no effect (P ≥ 0.42) on Clostridium strains, but as the dose increased SBEC concentrations increased (P = 0.001). Concentrations of the E. coli strain varied with dose. In vivo, LIPC's antimicrobial properties, at 15 g, significantly decreased (P = 0.02) SBEC when compared to 25 and 35 g dosages. C. perfringens decreased linearly (P = 0.03) as LIPC dose increased. Butyrate decreased linearly (P = 0.01) as LIPC dose increased. Further studies should be conducted with a longer dosing period to examine the antimicrobial properties of curcumin without adversely affecting cecal characteristics.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 22%
Researcher 5 19%
Student > Master 3 11%
Lecturer 2 7%
Student > Postgraduate 2 7%
Other 4 15%
Unknown 5 19%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 6 22%
Agricultural and Biological Sciences 5 19%
Biochemistry, Genetics and Molecular Biology 3 11%
Medicine and Dentistry 3 11%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Other 4 15%
Unknown 4 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2018.
All research outputs
#10,040,248
of 17,778,103 outputs
Outputs from Journal of Animal Science and Technology
#13
of 82 outputs
Outputs of similar age
#127,779
of 276,319 outputs
Outputs of similar age from Journal of Animal Science and Technology
#1
of 1 outputs
Altmetric has tracked 17,778,103 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 82 research outputs from this source. They receive a mean Attention Score of 1.9. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,319 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them