Title |
Absence of Batf3 results in reduced liver pathology in mice infected with Schistosoma japonicum
|
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Published in |
Parasites & Vectors, June 2017
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DOI | 10.1186/s13071-017-2250-1 |
Pubmed ID | |
Authors |
Lin Chen, Donghui Zhang, Wenyue Zhang, Yuxiao Zhu, Min Hou, Bingya Yang, Zhipeng Xu, Minjun Ji, Guanling Wu |
Abstract |
The involvement of CD8(+)T cells in schistosomiasis is being increasingly appreciated, but the underlying mechanism is not well defined. In this study, we showed that the absence of Batf3 alleviated liver damage in Batf3 (-/-) mice infected with S. japonicum. We found alleviated liver granulomatous inflammation in Batf3 (-/-) mice with schistosomiasis japonica could not be attributed to the difference in schistosome egg or worm burden. The stronger Tc1 cell responses observed in Batf3 (-/-) mice suggested that the deletion of Batf3 resulted in more activation of CD8(+)T cells unexpectedly during the natural infection of schistosomes. We detected a small amount of CD8α(+) DCs in the spleen of Batf3 (-/-) mice at 9w post-infection. This small amount of newly generated CD8α(+) DCs might contribute to enhanced activation of CD8(+)T cells via cross-presentation and activation which then attenuate hepatic pathological damage found in Batf3 (-/-) mice. Our study provides evidence that Batf3 is associated with the immunoregulation of the liver granuloma formation, which may confer a new options for schistosomiasis treatment. |
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United Kingdom | 1 | 50% |
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Science communicators (journalists, bloggers, editors) | 2 | 100% |
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Researcher | 1 | 17% |
Unknown | 3 | 50% |
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Immunology and Microbiology | 1 | 17% |
Unknown | 3 | 50% |