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Transcriptional responses to glucose in Saccharomyces cerevisiae strains lacking a functional protein kinase A

Overview of attention for article published in BMC Genomics, August 2011
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Title
Transcriptional responses to glucose in Saccharomyces cerevisiae strains lacking a functional protein kinase A
Published in
BMC Genomics, August 2011
DOI 10.1186/1471-2164-12-405
Pubmed ID
Authors

Daniela Livas, Marinka JH Almering, Jean-Marc Daran, Jack T Pronk, Juana M Gancedo

Abstract

The pattern of gene transcripts in the yeast Saccharomyces cerevisiae is strongly affected by the presence of glucose. An increased activity of protein kinase A (PKA), triggered by a rise in the intracellular concentration of cAMP, can account for many of the effects of glucose on transcription. In S. cerevisiae three genes, TPK1, TPK2, and TPK3, encode catalytic subunits of PKA. The lack of viability of tpk1 tpk2 tpk3 triple mutants may be suppressed by mutations such as yak1 or msn2/msn4. To investigate the requirement for PKA in glucose control of gene expression, we have compared the effects of glucose on global transcription in a wild-type strain and in two strains devoid of PKA activity, tpk1 tpk2 tpk3 yak1 and tpk1 tpk2 tpk3 msn2 msn4.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 2%
Sweden 1 2%
India 1 2%
Canada 1 2%
United States 1 2%
Unknown 50 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 29%
Researcher 9 16%
Student > Master 8 15%
Student > Doctoral Student 5 9%
Other 4 7%
Other 13 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 36 65%
Biochemistry, Genetics and Molecular Biology 8 15%
Engineering 3 5%
Computer Science 2 4%
Physics and Astronomy 2 4%
Other 3 5%
Unknown 1 2%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 August 2011.
All research outputs
#9,906,292
of 12,373,620 outputs
Outputs from BMC Genomics
#5,684
of 7,296 outputs
Outputs of similar age
#67,944
of 86,393 outputs
Outputs of similar age from BMC Genomics
#10
of 22 outputs
Altmetric has tracked 12,373,620 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,296 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.