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Diabetes - Perspectives in Drug Therapy

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Cover of 'Diabetes - Perspectives in Drug Therapy'

Table of Contents

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    Book Overview
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    Chapter 1 Targeting type 2 diabetes.
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    Chapter 2 Dual acting and pan-PPAR activators as potential anti-diabetic therapies.
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    Chapter 3 GLP-1 agonists and dipeptidyl-peptidase IV inhibitors.
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    Chapter 4 Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes.
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    Chapter 5 SGLT inhibitors as new therapeutic tools in the treatment of diabetes.
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    Chapter 6 Inhibitors of 11β-hydroxysteroid dehydrogenase type 1 in antidiabetic therapy.
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    Chapter 7 Nampt and its potential role in inflammation and type 2 diabetes.
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    Chapter 8 Inhibition of ganglioside biosynthesis as a novel therapeutic approach in insulin resistance.
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    Chapter 9 Overcoming Insulin Resistance with Ciliary Neurotrophic Factor
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    Chapter 10 Thermogenesis and related metabolic targets in anti-diabetic therapy.
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    Chapter 11 Interleukin-targeted therapy for metabolic syndrome and type 2 diabetes.
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    Chapter 12 Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes.
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    Chapter 13 AMP-activated protein kinase and metabolic control.
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    Chapter 14 Mitochondria as potential targets in antidiabetic therapy.
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    Chapter 15 Research and development of glucokinase activators for diabetes therapy: theoretical and practical aspects.
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    Chapter 16 Erratum to Chapter 11: Interleukin-Targeted Therapy for Metabolic Syndrome and Type 2 Diabetes
Attention for Chapter 9: Overcoming Insulin Resistance with Ciliary Neurotrophic Factor
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Chapter title
Overcoming Insulin Resistance with Ciliary Neurotrophic Factor
Chapter number 9
Book title
Diabetes - Perspectives in Drug Therapy
Published in
Handbook of experimental pharmacology, January 2011
DOI 10.1007/978-3-642-17214-4_9
Pubmed ID
Book ISBNs
978-3-64-217213-7, 978-3-64-217214-4
Authors

Tamara L. Allen, Vance B. Matthews, Mark A. Febbraio

Editors

Prof.Dr.Dr. Mathias Schwanstecher

Abstract

The incidence of obesity and related co-morbidities such as insulin resistance, dyslipidemia and hypertension are increasing at an alarming rate worldwide. Current interventions seem ineffective to halt this progression. With the failure of leptin as an anti-obesity therapeutic, ciliary neurotrophic factor (CNTF) has proven efficacious in models of obesity and leptin resistance, where leptin proved ineffective. CNTF is a gp130 ligand that has been found to act centrally and peripherally to promote weight loss and insulin sensitivity in both human and rodent models. Future research into novel gp130 ligands may offer new candidates for obesity-related drug therapy.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 22%
Student > Master 4 22%
Student > Bachelor 3 17%
Professor 1 6%
Other 1 6%
Other 2 11%
Unknown 3 17%
Readers by discipline Count As %
Medicine and Dentistry 6 33%
Agricultural and Biological Sciences 3 17%
Nursing and Health Professions 2 11%
Pharmacology, Toxicology and Pharmaceutical Science 1 6%
Social Sciences 1 6%
Other 1 6%
Unknown 4 22%