Chapter title |
Overcoming Insulin Resistance with Ciliary Neurotrophic Factor
|
---|---|
Chapter number | 9 |
Book title |
Diabetes - Perspectives in Drug Therapy
|
Published in |
Handbook of experimental pharmacology, January 2011
|
DOI | 10.1007/978-3-642-17214-4_9 |
Pubmed ID | |
Book ISBNs |
978-3-64-217213-7, 978-3-64-217214-4
|
Authors |
Tamara L. Allen, Vance B. Matthews, Mark A. Febbraio |
Editors |
Prof.Dr.Dr. Mathias Schwanstecher |
Abstract |
The incidence of obesity and related co-morbidities such as insulin resistance, dyslipidemia and hypertension are increasing at an alarming rate worldwide. Current interventions seem ineffective to halt this progression. With the failure of leptin as an anti-obesity therapeutic, ciliary neurotrophic factor (CNTF) has proven efficacious in models of obesity and leptin resistance, where leptin proved ineffective. CNTF is a gp130 ligand that has been found to act centrally and peripherally to promote weight loss and insulin sensitivity in both human and rodent models. Future research into novel gp130 ligands may offer new candidates for obesity-related drug therapy. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 22% |
Student > Master | 4 | 22% |
Student > Bachelor | 3 | 17% |
Professor | 1 | 6% |
Other | 1 | 6% |
Other | 2 | 11% |
Unknown | 3 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 33% |
Agricultural and Biological Sciences | 3 | 17% |
Nursing and Health Professions | 2 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Social Sciences | 1 | 6% |
Other | 1 | 6% |
Unknown | 4 | 22% |