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Modulation of endothelial function by Toll like receptors

Overview of attention for article published in Pharmacological Research, June 2016
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Mentioned by

twitter
2 tweeters

Readers on

mendeley
23 Mendeley
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Title
Modulation of endothelial function by Toll like receptors
Published in
Pharmacological Research, June 2016
DOI 10.1016/j.phrs.2016.03.038
Pubmed ID
Authors

Beatriz Salvador, Alicia Arranz, Sara Francisco, Laura Córdoba, Carmen Punzón, Miguel Ángel Llamas, Manuel Fresno

Abstract

Endothelial cells (EC) are able to actively control vascular permeability, coagulation, blood pressure and angiogenesis. Most recently, a role for endothelial cells in the immune response has been described. Therefore, the endothelium has a dual role controlling homeostasis but also being the first line for host defence and tissue damage repair thanks to its ability to mount an inflammatory response. Endothelial cells have been shown to express pattern-recognition receptors (PPR) including Toll-like receptors (TLR) that are activated in response to stimuli within the bloodstream including pathogens and damage signals. TLRs are strategic mediators of the immune response in endothelial cells but they also regulate the angiogenic process critical for tissue repair. Nevertheless, endothelial activation and angiogenesis can contribute to some pathologies. Thus, inappropriate endothelial activation, also known as endothelial dysfunction, through TLRs contributes to tissue damage during autoimmune and inflammatory diseases such as atherosclerosis, hypertension, ischemia and diabetes associated cardiovascular diseases. Also TLR induced angiogenesis is required for the growth of some tumors, atherosclerosis and rheumatoid arthritis, among others. In this review we discuss the importance of various TLRs in modulating the activation of endothelial cells and their importance in immunity to infection and vascular disease as well as their potential as therapeutic targets.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 1 4%
Unknown 22 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 22%
Student > Bachelor 4 17%
Student > Doctoral Student 3 13%
Researcher 3 13%
Professor 2 9%
Other 6 26%
Readers by discipline Count As %
Medicine and Dentistry 13 57%
Biochemistry, Genetics and Molecular Biology 4 17%
Agricultural and Biological Sciences 3 13%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Nursing and Health Professions 1 4%
Other 1 4%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 June 2017.
All research outputs
#4,089,082
of 8,148,623 outputs
Outputs from Pharmacological Research
#374
of 794 outputs
Outputs of similar age
#85,979
of 174,354 outputs
Outputs of similar age from Pharmacological Research
#14
of 28 outputs
Altmetric has tracked 8,148,623 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 794 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 174,354 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.