Title |
Organelle communication: Signaling crossroads between homeostasis and disease
|
---|---|
Published in |
International Journal of Biochemistry & Cell Biology, February 2014
|
DOI | 10.1016/j.biocel.2014.01.019 |
Pubmed ID | |
Authors |
Roberto Bravo-Sagua, Natalia Torrealba, Felipe Paredes, Pablo E. Morales, Christian Pennanen, Camila López-Crisosto, Rodrigo Troncoso, Alfredo Criollo, Mario Chiong, Joseph A. Hill, Thomas Simmen, Andrew F. Quest, Sergio Lavandero |
Abstract |
Cellular organelles do not function as isolated or static units, but rather form dynamic contacts between one another that can be modulated according to cellular needs. The physical interfaces between organelles are important for Ca2+ and lipid homeostasis, and serve as platforms for the control of many essential functions including metabolism, signaling, organelle integrity and execution of the apoptotic program. Emerging evidence also highlights the importance of organelle communication in disorders such as Alzheimer's disease, pulmonary arterial hypertension, cancer, skeletal and cardiac muscle dysfunction. Here, we provide an overview of the current literature on organelle communication and the link to human pathologies. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 1% |
Chile | 1 | 1% |
Unknown | 92 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 26 | 28% |
Student > Master | 13 | 14% |
Researcher | 12 | 13% |
Student > Doctoral Student | 8 | 9% |
Student > Bachelor | 7 | 7% |
Other | 17 | 18% |
Unknown | 11 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 25 | 27% |
Biochemistry, Genetics and Molecular Biology | 24 | 26% |
Medicine and Dentistry | 8 | 9% |
Neuroscience | 7 | 7% |
Engineering | 4 | 4% |
Other | 9 | 10% |
Unknown | 17 | 18% |