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Sweet-talk: role of host glycosylation in bacterial pathogenesis of the gastrointestinal tract

Overview of attention for article published in Gut, January 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

twitter
6 tweeters
patent
1 patent
facebook
2 Facebook pages

Citations

dimensions_citation
136 Dimensions

Readers on

mendeley
255 Mendeley
citeulike
3 CiteULike
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Title
Sweet-talk: role of host glycosylation in bacterial pathogenesis of the gastrointestinal tract
Published in
Gut, January 2011
DOI 10.1136/gut.2010.212704
Pubmed ID
Authors

A. P. Moran, A. Gupta, L. Joshi

Abstract

Glycosylation is a key modification of proteins and lipids and is involved in most intermolecular and intercellular interactions. The gastrointestinal mucus gel is continuous and can be divided into two layers: a secreted loosely associated layer and a layer firmly attached to the mucosa. In addition, the membrane-bound glycosylated proteins and lipids create a glycocalyx, which remains adherent on each cell and is dynamic and responsive to the physiological state and environment of the cell. The secreted glycans form a mucus gel layer that serves as a physicochemical sensor and barrier network and is primarily composed of mucins and associated peptides. These glycans protect gut epithelial cells from chemical, biological and physical insults and are continuously renewed. Pathogens colonise and invade the host epithelial cells using protein-protein and glycan-lectin interactions. During the process of colonisation and infection, the glycosylation state of both host and pathogen change in response to the presence of the other. This complex modulation of glycan expression critically determines pathogenesis and the host response in terms of structural changes and immune response. In addition, by influencing host immunity and gut glycosylation, the microbiota can further effect protection against pathogens. In this review, the roles of host glycosylation in interactions with two prevalent bacterial pathogens, Campylobater jejuni and Helicobacter pylori, are discussed to illustrate important concepts in pathogenesis.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 255 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 1%
France 2 <1%
Spain 2 <1%
India 1 <1%
Ireland 1 <1%
Brazil 1 <1%
Unknown 245 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 62 24%
Researcher 55 22%
Student > Master 38 15%
Student > Bachelor 30 12%
Student > Doctoral Student 14 5%
Other 38 15%
Unknown 18 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 105 41%
Biochemistry, Genetics and Molecular Biology 44 17%
Medicine and Dentistry 25 10%
Immunology and Microbiology 23 9%
Chemistry 16 6%
Other 18 7%
Unknown 24 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2020.
All research outputs
#3,288,476
of 16,849,755 outputs
Outputs from Gut
#1,648
of 5,874 outputs
Outputs of similar age
#19,621
of 96,151 outputs
Outputs of similar age from Gut
#7
of 44 outputs
Altmetric has tracked 16,849,755 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,874 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.3. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 96,151 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.