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Environmental insults: critical triggers for amyotrophic lateral sclerosis

Overview of attention for article published in Translational Neurodegeneration, June 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#41 of 111)
  • Good Attention Score compared to outputs of the same age (76th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

news
1 news outlet

Citations

dimensions_citation
19 Dimensions

Readers on

mendeley
40 Mendeley
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Title
Environmental insults: critical triggers for amyotrophic lateral sclerosis
Published in
Translational Neurodegeneration, June 2017
DOI 10.1186/s40035-017-0087-3
Pubmed ID
Authors

Bing Yu, Roger Pamphlett

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by a rapid loss of lower and upper motor neurons. As a complex disease, the ageing process and complicated gene-environment interactions are involved in the majority of cases. Significant advances have been made in unravelling the genetic susceptibility to ALS with massively parallel sequencing technologies, while environmental insults remain a suspected but largely unexplored source of risk. Several studies applying the strategy of Mendelian randomisation have strengthened the link between environmental insults and ALS, but none so far has proved conclusive. We propose a new ALS model which links the current knowledge of genetic factors, ageing and environmental insults. This model provides a mechanism as to how ALS is initiated, with environmental insults playing a critical role. The available evidence has suggested that inherited defect(s) could cause mitochondrial dysfunction, which would establish the primary susceptibility to ALS. Further study of the underlying mechanism may shed light on ALS pathogenesis. Environmental insults are a critical trigger for ALS, particularly in the aged individuals with other toxicant susceptible genes. The identification of ALS triggers could lead to preventive strategies for those individuals at risk.

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 20%
Student > Master 8 20%
Student > Bachelor 6 15%
Researcher 5 13%
Other 3 8%
Other 1 3%
Unknown 9 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 18%
Medicine and Dentistry 6 15%
Biochemistry, Genetics and Molecular Biology 5 13%
Neuroscience 4 10%
Nursing and Health Professions 1 3%
Other 5 13%
Unknown 12 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 June 2017.
All research outputs
#1,671,382
of 11,411,580 outputs
Outputs from Translational Neurodegeneration
#41
of 111 outputs
Outputs of similar age
#58,042
of 260,963 outputs
Outputs of similar age from Translational Neurodegeneration
#2
of 5 outputs
Altmetric has tracked 11,411,580 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 111 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.8. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,963 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.