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Therapeutic effect of low molecular weight chitosan containing sepia ink on ethanol-induced gastric ulcer in rats

Overview of attention for article published in Acta Cirurgica Brasileira, December 2016
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Title
Therapeutic effect of low molecular weight chitosan containing sepia ink on ethanol-induced gastric ulcer in rats
Published in
Acta Cirurgica Brasileira, December 2016
DOI 10.1590/s0102-865020160120000006
Pubmed ID
Authors

Wei Zhang, Kang Liu, Lei Li, Yingxin Li, Xianxian Sui, Yinzhu Rao, Jiahao Wu, Qiuping Wu

Abstract

To evaluate the role of low molecular chitosan containing sepia ink (LMCS) in ethanol-induced (5 ml/kg) gastric ulcer in rats. Animals were divided into four groups (n = 12): normal group (Normal), negative control group (Con), experiment group (LMCS) and positive control Omeprazole group (OMZ). Gastric empty rate was detected in the first 7 days. Rats were sacrificed at 7, 14 and 21 day for histology and ELISA detections. Gastric empty was no significant differences among the groups (P > 0.05). Histological observation showed gastric mucosal LMCS treated had better healing effect. Hydroxyproline (Hyp) was significantly increased from 7 day (P < 0.05). LMCS significantly inhibited malondialdehyde (MDA) generation for lipid peroxidation from 7 day (P < 0.05). LMCS significantly promoted the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) at the earlier stage (P < 0.05). OMZ had the similar effects above. As for myeloperoxidase (MPO), LMCS significantly decreased and restored it to normal levels from 7 day (P < 0.05), it is earlier than OMZ which is from 14 day. LMCS can improve gastric mucosa tissue repair, exert significant influences on oxidative and antioxidant enzyme activities and neutrophil infiltration.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 25%
Lecturer 3 19%
Student > Bachelor 1 6%
Student > Doctoral Student 1 6%
Professor 1 6%
Other 3 19%
Unknown 3 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 19%
Chemistry 2 13%
Pharmacology, Toxicology and Pharmaceutical Science 2 13%
Environmental Science 1 6%
Agricultural and Biological Sciences 1 6%
Other 1 6%
Unknown 6 38%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2017.
All research outputs
#9,142,755
of 11,419,765 outputs
Outputs from Acta Cirurgica Brasileira
#78
of 117 outputs
Outputs of similar age
#189,493
of 260,536 outputs
Outputs of similar age from Acta Cirurgica Brasileira
#3
of 5 outputs
Altmetric has tracked 11,419,765 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 117 research outputs from this source. They receive a mean Attention Score of 1.5. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,536 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.