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Probiotic therapy reduces inflammation and improves intestinal morphology in rats with induced oral mucositis

Overview of attention for article published in Brazilian Oral Research, January 2017
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Title
Probiotic therapy reduces inflammation and improves intestinal morphology in rats with induced oral mucositis
Published in
Brazilian Oral Research, January 2017
DOI 10.1590/1807-3107bor-2017.vol31.0071
Pubmed ID
Authors

Dayana GERHARD, Frederico José da Silva Simão de SOUSA, Rodrigo Antonio Carvalho ANDRAUS, Paulo Eduardo PARDO, Gisele Alborguetti NAI, Hermann Bremer NETO, Michel Reis MESSORA, Luciana Prado MAIA

Abstract

The aim of the present study was to evaluate the effect of systemic administration of probiotics (PROB) on the progression of experimentally induced oral and intestinal mucositis in rats immunosuppressed by chemotherapy (5-fluorouracil: 5-FU). Twenty-four rats were divided into the following groups (n=6): GC (control), GPROB, G5FU and G5-FU/PROB. Groups GPROB and G5-FU/PROB received 1 g of probiotic incorporated into each 100 g of feed (Bacillus subtilis, Bifidobacterium bifidum, Enterococcus faecium and Lactobacilllus acidophilus), beginning 30 days before oral mucositis induction. Groups G5FU and G5-FU/PROB received 60 mg/kg of 5-FU on days 0 and 2. The left oral mucosa of each animal was irritated by mechanical trauma (days 1 and 2). On days 3 and 7, three animals from each group were sacrificed, and their oral mucosa and small intestine were biopsied and processed for histopathological analysis. Groups G5-FU and G5-FU/PROB showed ulcerated oral lesions at day 3, with progression in group G5-FU and regression in group G5-FU/PROB at day 7. Histologically, less severe signs of inflammation in the oral mucosa were observed in group G5-FU/PROB than in group G5-FU. Regarding the intestine, villus-related defects of lesser magnitude were observed in group G5-FU/PROB, compared with group G5-FU. Group GPROB showed greater villus height than group GC. It can be concluded that probiotic supplementation reduced oral and intestinal inflammation in immunosuppressed rats with experimentally induced mucositis, and may protect the intestine from changes induced by chemotherapy, thus contributing to overall health.

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Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 47 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 17%
Other 5 11%
Student > Bachelor 5 11%
Professor 5 11%
Student > Doctoral Student 4 9%
Other 8 17%
Unknown 12 26%
Readers by discipline Count As %
Medicine and Dentistry 12 26%
Agricultural and Biological Sciences 7 15%
Nursing and Health Professions 4 9%
Immunology and Microbiology 2 4%
Biochemistry, Genetics and Molecular Biology 2 4%
Other 6 13%
Unknown 14 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2017.
All research outputs
#14,120,426
of 16,016,553 outputs
Outputs from Brazilian Oral Research
#132
of 161 outputs
Outputs of similar age
#228,539
of 268,856 outputs
Outputs of similar age from Brazilian Oral Research
#1
of 1 outputs
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So far Altmetric has tracked 161 research outputs from this source. They receive a mean Attention Score of 2.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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