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Investigations of the prevalence and virulence of Candida albicans in periodontal and endodontic lesions in diabetic and normoglycemic patients

Overview of attention for article published in Journal of Applied Oral Science, June 2017
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Title
Investigations of the prevalence and virulence of Candida albicans in periodontal and endodontic lesions in diabetic and normoglycemic patients
Published in
Journal of Applied Oral Science, June 2017
DOI 10.1590/1678-7757-2016-0432
Pubmed ID
Authors

Cinthya Cristina GOMES, Ludmila Silva GUIMARÃES, Larissa Christina Costa PINTO, Gabriela Alessandra da Cruz Galhardo CAMARGO, Maria Isabel Bastos VALENTE, Maria Inêz de Moura SARQUIS

Abstract

The aim of this study was to investigate the prevalence of isolated Candida albicans from periodontal endodontic lesions in diabetic and normoglycemic patients, and the fungi's virulence in different atmospheric conditions. A case-control study was conducted on 15 patients with type 2 diabetes mellitus (G1) and 15 non-diabetics (G2) with periodontal endodontic lesions. Samples of root canals and periodontal pockets were plated on CHROMagar for later identification by polymerase chain reaction (PCR) and virulence test. C. albicans was identified in 79.2% and 20.8% of the 60 samples collected from diabetic and normoglycemic patients, respectively. Of the 30 samples collected from periodontal pockets, 13 showed a positive culture for C. albicans, with 77% belonging to G1 and 23% to G2. Of the 11 positive samples from root canals, 82% were from G1 and 18% from G2. Production of proteinase presented a precipitation zone Pz<0.63 of 100% in G1 and 72% in G2, in redox and negative (Pz=1), under anaerobic conditions in both groups. Hydrophobicity of the strains from G1 indicated 16.4% with low, 19.3% with moderate, and 64.3% with high hydrophobicity in redox. In G2, 42.2% had low, 39.8% had moderate, 18% had high hydrophobicity in redox. In anaerobic conditions, G1 showed 15.2% with low, 12.8% with moderate, and 72% with high hydrophobicity; in G2, 33.6% had low, 28.8% had moderate, and 37.6% had high hydrophobicity. There was statistical difference in the number of positive cultures between G1 and G2 (p<0.05) with predominance in G1. There was statistical difference for all virulence factors, except hemolysis (p=0.001). Candida albicans was isolated more frequently and had higher virulence in diabetic patients.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 62 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 19%
Student > Ph. D. Student 7 11%
Student > Doctoral Student 6 10%
Student > Bachelor 5 8%
Researcher 4 6%
Other 16 26%
Unknown 12 19%
Readers by discipline Count As %
Medicine and Dentistry 32 52%
Agricultural and Biological Sciences 4 6%
Immunology and Microbiology 2 3%
Biochemistry, Genetics and Molecular Biology 2 3%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 5 8%
Unknown 15 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2017.
All research outputs
#14,120,513
of 16,016,553 outputs
Outputs from Journal of Applied Oral Science
#186
of 229 outputs
Outputs of similar age
#228,522
of 268,836 outputs
Outputs of similar age from Journal of Applied Oral Science
#4
of 6 outputs
Altmetric has tracked 16,016,553 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 229 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.