Title |
Impacts of mutation effects and population size on mutation rate in asexual populations: a simulation study
|
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Published in |
BMC Ecology and Evolution, September 2010
|
DOI | 10.1186/1471-2148-10-298 |
Pubmed ID | |
Authors |
Xiaoqian Jiang, Baolin Mu, Zhuoran Huang, Mingjing Zhang, Xiaojuan Wang, Shiheng Tao |
Abstract |
In any natural population, mutation is the primary source of genetic variation required for evolutionary novelty and adaptation. Nevertheless, most mutations, especially those with phenotypic effects, are harmful and are consequently removed by natural selection. For this reason, under natural selection, an organism will evolve to a lower mutation rate. Overall, the action of natural selection on mutation rate is related to population size and mutation effects. Although theoretical work has intensively investigated the relationship between natural selection and mutation rate, most of these studies have focused on individual competition within a population, rather than on competition among populations. The aim of the present study was to use computer simulations to investigate how natural selection adjusts mutation rate among asexually reproducing subpopulations with different mutation rates. |
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