Title |
A two years longitudinal study of a transgenic Huntington disease monkey
|
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Published in |
BMC Neuroscience, March 2014
|
DOI | 10.1186/1471-2202-15-36 |
Pubmed ID | |
Authors |
Anthony WS Chan, Yan Xu, Jie Jiang, Tayeb Rahim, Dongming Zhao, Jannet Kocerha, Tim Chi, Sean Moran, Heidi Engelhardt, Katherine Larkin, Adam Neumann, Haiying Cheng, Chunxia Li, Katie Nelson, Heather Banta, Stuart M Zola, Francois Villinger, Jinjing Yang, Claudia M Testa, Hui Mao, Xiaodong Zhang, Jocelyne Bachevalier |
Abstract |
A two-year longitudinal study composed of morphometric MRI measures and cognitive behavioral evaluation was performed on a transgenic Huntington's disease (HD) monkey. rHD1, a transgenic HD monkey expressing exon 1 of the human gene encoding huntingtin (HTT) with 29 CAG repeats regulated by a human polyubiquitin C promoter was used together with four age-matched wild-type control monkeys. This is the first study on a primate model of human HD based on longitudinal clinical measurements. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
China | 1 | 2% |
Austria | 1 | 2% |
Unknown | 56 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 14 | 24% |
Researcher | 9 | 15% |
Student > Bachelor | 5 | 8% |
Professor > Associate Professor | 5 | 8% |
Student > Doctoral Student | 4 | 7% |
Other | 7 | 12% |
Unknown | 15 | 25% |
Readers by discipline | Count | As % |
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Neuroscience | 15 | 25% |
Agricultural and Biological Sciences | 9 | 15% |
Medicine and Dentistry | 6 | 10% |
Psychology | 6 | 10% |
Engineering | 3 | 5% |
Other | 3 | 5% |
Unknown | 17 | 29% |