↓ Skip to main content

Cell Microencapsulation

Overview of attention for book
Cover of 'Cell Microencapsulation'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Cell Microencapsulation
  3. Altmetric Badge
    Chapter 2 Applications of Cell Microencapsulation
  4. Altmetric Badge
    Chapter 3 Cell Microencapsulation: Dripping Methods
  5. Altmetric Badge
    Chapter 4 Field Effect Microparticle Generation for Cell Microencapsulation
  6. Altmetric Badge
    Chapter 5 Microfluidic Approach to Cell Microencapsulation
  7. Altmetric Badge
    Chapter 6 Polymeric Materials for Cell Microencapsulation
  8. Altmetric Badge
    Chapter 7 Polymeric Materials for Perm-Selective Coating of Alginate Microbeads
  9. Altmetric Badge
    Chapter 8 Determination of the Mechanical Strength of Microcapsules
  10. Altmetric Badge
    Chapter 9 The Diffusive Properties of Hydrogel Microcapsules for Cell Encapsulation
  11. Altmetric Badge
    Chapter 10 Methods for Incorporating Oxygen-Generating Biomaterials into Cell Culture and Microcapsule Systems
  12. Altmetric Badge
    Chapter 11 Noninvasive Tracking of Alginate-Microencapsulated Cells
  13. Altmetric Badge
    Chapter 12 Retrieval of Microencapsulated Islet Grafts for Post-transplant Evaluation
  14. Altmetric Badge
    Chapter 13 A Method of Porcine Pancreatic Islet Isolation for Microencapsulation
  15. Altmetric Badge
    Chapter 14 Selective Osmotic Shock (SOS)-Based Islet Isolation for Microencapsulation
  16. Altmetric Badge
    Chapter 15 Preparation and Characterization of Alginate–Chitosan Microcapsule for Hepatocyte Culture
  17. Altmetric Badge
    Chapter 16 Use of Flow Focusing Technique for Microencapsulation of Myoblasts
  18. Altmetric Badge
    Chapter 17 Alginate Microbeads for Cell and Protein Delivery
  19. Altmetric Badge
    Chapter 18 Compartmentalization of Two Cell Types in Multilayered Alginate Microcapsules
  20. Altmetric Badge
    Chapter 19 Primary Choroid Plexus Tissue for Use in Cellular Therapy
  21. Altmetric Badge
    Chapter 20 Cell Microencapsulation
  22. Altmetric Badge
    Chapter 21 Microencapsulated Cells for Cancer Therapy
  23. Altmetric Badge
    Chapter 22 Microencapsulation of Bacterial Cells by Emulsion Technique for Probiotic Application
  24. Altmetric Badge
    Chapter 23 Microencapsulation of Islets for the Treatment of Type 1 Diabetes Mellitus (T1D)
  25. Altmetric Badge
    Chapter 24 Cell Microencapsulation
  26. Altmetric Badge
    Chapter 25 Microencapsulation in Clinical Islet Xenotransplantation
  27. Altmetric Badge
    Chapter 26 Methods for Microencapsulated Porcine Islet Production
  28. Altmetric Badge
    Chapter 27 Microencapsulation of Parathyroid Cells for the Treatment of Hypoparathyroidism
Attention for Chapter 24: Cell Microencapsulation
Altmetric Badge

Readers on

mendeley
18 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Chapter title
Cell Microencapsulation
Chapter number 24
Book title
Cell Microencapsulation
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-6364-5_24
Pubmed ID
Book ISBNs
978-1-4939-6362-1, 978-1-4939-6364-5
Authors

Krishnan, Rahul, Ko, David, Foster, Clarence E, Liu, Wendy, Smink, A M, de Haan, Bart, De Vos, Paul, Lakey, Jonathan R T, Foster, Clarence E., Smink, A. M., Lakey, Jonathan R. T., Rahul Krishnan, David Ko, Clarence E. Foster III, Wendy Liu, A. M. Smink, Bart de Haan, Paul De Vos, Jonathan R. T. Lakey, Clarence E. Foster

Editors

Emmanuel C. Opara

Abstract

Transplantation of alginate-encapsulated islets has the potential to treat patients suffering from type I diabetes, a condition characterized by an autoimmune attack against insulin-secreting beta cells. However, there are multiple immunological challenges associated with this procedure, all of which must be adequately addressed prior to translation from trials in small animal and nonhuman primate models to human clinical trials. Principal threats to graft viability include immune-mediated destruction triggered by immunogenic alginate impurities, unfavorable polymer composition and surface characteristics, and release of membrane-permeable antigens, as well as damage associated molecular patterns (DAMPs) by the encapsulated islets themselves. The lack of standardization of significant parameters of bioencapsulation device design and manufacture (i.e., purification protocols, surface-modification grafting techniques, alginate composition modifications) between labs is yet another obstacle that must be overcome before a clinically effective and applicable protocol for encapsulating islets can be implemented. Nonetheless, substantial progress is being made, as is evident from prolonged graft survival times and improved protection from immune-mediated graft destruction reported by various research groups, but also with regard to discoveries of specific pathways involved in explaining observed outcomes. Progress in the latter is essential for a comprehensive understanding of the mechanisms responsible for the varying levels of immunogenicity of certain alginate devices. Successful translation of encapsulated islet transplantation from in vitro and animal model testing to human clinical trials hinges on application of this knowledge of the pathways and interactions which comprise immune-mediated rejection. Thus, this review not only focuses on the different factors contributing to provocation of the immune reaction by encapsulated islets, but also on the defining characteristics of the response itself.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 28%
Researcher 4 22%
Student > Bachelor 3 17%
Student > Postgraduate 2 11%
Student > Master 2 11%
Other 1 6%
Unknown 1 6%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 28%
Pharmacology, Toxicology and Pharmaceutical Science 3 17%
Medicine and Dentistry 3 17%
Immunology and Microbiology 2 11%
Engineering 2 11%
Other 1 6%
Unknown 2 11%