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Cell Microencapsulation

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Cover of 'Cell Microencapsulation'

Table of Contents

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    Book Overview
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    Chapter 1 Cell Microencapsulation
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    Chapter 2 Applications of Cell Microencapsulation
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    Chapter 3 Cell Microencapsulation: Dripping Methods
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    Chapter 4 Field Effect Microparticle Generation for Cell Microencapsulation
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    Chapter 5 Microfluidic Approach to Cell Microencapsulation
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    Chapter 6 Polymeric Materials for Cell Microencapsulation
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    Chapter 7 Polymeric Materials for Perm-Selective Coating of Alginate Microbeads
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    Chapter 8 Determination of the Mechanical Strength of Microcapsules
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    Chapter 9 The Diffusive Properties of Hydrogel Microcapsules for Cell Encapsulation
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    Chapter 10 Methods for Incorporating Oxygen-Generating Biomaterials into Cell Culture and Microcapsule Systems
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    Chapter 11 Noninvasive Tracking of Alginate-Microencapsulated Cells
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    Chapter 12 Retrieval of Microencapsulated Islet Grafts for Post-transplant Evaluation
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    Chapter 13 A Method of Porcine Pancreatic Islet Isolation for Microencapsulation
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    Chapter 14 Selective Osmotic Shock (SOS)-Based Islet Isolation for Microencapsulation
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    Chapter 15 Preparation and Characterization of Alginate–Chitosan Microcapsule for Hepatocyte Culture
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    Chapter 16 Use of Flow Focusing Technique for Microencapsulation of Myoblasts
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    Chapter 17 Alginate Microbeads for Cell and Protein Delivery
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    Chapter 18 Compartmentalization of Two Cell Types in Multilayered Alginate Microcapsules
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    Chapter 19 Primary Choroid Plexus Tissue for Use in Cellular Therapy
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    Chapter 20 Cell Microencapsulation
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    Chapter 21 Microencapsulated Cells for Cancer Therapy
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    Chapter 22 Microencapsulation of Bacterial Cells by Emulsion Technique for Probiotic Application
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    Chapter 23 Microencapsulation of Islets for the Treatment of Type 1 Diabetes Mellitus (T1D)
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    Chapter 24 Cell Microencapsulation
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    Chapter 25 Microencapsulation in Clinical Islet Xenotransplantation
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    Chapter 26 Methods for Microencapsulated Porcine Islet Production
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    Chapter 27 Microencapsulation of Parathyroid Cells for the Treatment of Hypoparathyroidism
Attention for Chapter 9: The Diffusive Properties of Hydrogel Microcapsules for Cell Encapsulation
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Chapter title
The Diffusive Properties of Hydrogel Microcapsules for Cell Encapsulation
Chapter number 9
Book title
Cell Microencapsulation
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-6364-5_9
Pubmed ID
Book ISBNs
978-1-4939-6362-1, 978-1-4939-6364-5

D. M. Lavin, B. E. Bintz, C. G. Thanos Ph.D., C. G. Thanos


Emmanuel C. Opara


Hydrogel microcapsules have been used for decades to encapsulate cells and treat diseases ranging from neurodegenerative disorders to more systemic applications like Type I Diabetes. This cell encapsulation modality has been developed through more cumulative experiments than perhaps any other, owing to the relative ease of accessing the required materials, the commercial availability of droplet-generating instrumentation, and the mild microenvironment and unique permeability properties of hydrogels that are difficult to attain with alternative encapsulation systems employing thermoplastic materials. Because of their size and shape, microcapsules have an inherent advantage over macroencapsulation devices due to the more favorable surface area to volume ratio, which allows for greater efficiency in the amount of cellular cargo that is entrapped and enhanced nutrient exchange and efflux of secreted products. Unfortunately, with this significant positive benefit comes the caveat of difficult or impractical retrievability, highlighting the paradox that is particularly relevant as differentiated stem cell sources become more readily available. This chapter focuses on several techniques that can be used to evaluate the permeability and pore structure of hydrogel microcapsules, including a simplistic model for describing the diffusive behavior of alginate-polycation-alginate (APA) microcapsules with a liquid core, and an ancillary method to evaluate the ultrastructure of the APA membrane including morphometric analysis.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 40%
Other 3 30%
Researcher 1 10%
Unknown 2 20%
Readers by discipline Count As %
Engineering 4 40%
Agricultural and Biological Sciences 1 10%
Biochemistry, Genetics and Molecular Biology 1 10%
Psychology 1 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 10%
Other 0 0%
Unknown 2 20%