Selective Expression of Galanin in Neuronal-Like Cells of the Human Carotid Body.
Arterial Chemoreceptors in Physiology and Pathophysiology
Advances in experimental medicine and biology, January 2015
Di Giulio, Camillo, Marconi, Guya Diletta, Zara, Susi, Di Tano, Andrea, Porzionato, Andrea, Pokorski, Mieczyslaw, Cataldi, Amelia, Mazzatenta, Andrea, Camillo Di Giulio, Guya Diletta Marconi, Susi Zara, Andrea Di Tano, Andrea Porzionato, Mieczyslaw Pokorski, Amelia Cataldi, Andrea Mazzatenta
The carotid body is a neural-crest-derived organ devoted to respiratory homeostasis through sensing changes in blood oxygen levels. The sensory units are the glomeruli composed of clusters of neuronal-like (type I) cells surrounded by glial-like (type II) cells. During chronic hypoxia, the carotid body shows growth, with increasing neuronal-like cell numbers. We are interested in the signals involved in the mechanisms that underlie such response, because they are not well understood and described. Considering that, in literature, galanin is involved in neurotrophic or neuroprotective role in cell proliferation and is expressed in animal carotid body, we investigated its expression in human. Here, we have shown the expression and localisation of galanin in the human carotid body.
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