Chapter title |
Neurotrophic Properties, Chemosensory Responses and Neurogenic Niche of the Human Carotid Body.
|
---|---|
Chapter number | 16 |
Book title |
Arterial Chemoreceptors in Physiology and Pathophysiology
|
Published in |
Advances in experimental medicine and biology, January 2015
|
DOI | 10.1007/978-3-319-18440-1_16 |
Pubmed ID | |
Book ISBNs |
978-3-31-918439-5, 978-3-31-918440-1
|
Authors |
Ortega-Sáenz, Patricia, Villadiego, Javier, Pardal, Ricardo, Toledo-Aral, Juan José, López-Barneo, José, Patricia Ortega-Sáenz, Javier Villadiego, Ricardo Pardal, Juan José Toledo-Aral, José López-Barneo |
Abstract |
The carotid body (CB) is a polymodal chemoreceptor that triggers the hyperventilatory response to hypoxia necessary for the maintenance of O2 homeostasis essential for the survival of organs such as the brain or heart. Glomus cells, the sensory elements in the CB, are also sensitive to hypercapnia, acidosis and, although less generally accepted, hypoglycemia. Current knowledge on CB function is mainly based on studies performed on lower mammals, but the information on the human CB is scant. Here we describe the structure, neurotrophic properties, and cellular responses to hypoxia and hypoglycemia of CBs dissected from human cadavers. The adult CB parenchyma contains clusters of chemosensitive glomus (type I) and sustentacular (type II) cells as well as nestin-positive progenitor cells. This organ also expresses high levels of the dopaminotrophic glial cell line-derived neurotrophic factor (GDNF). GDNF production and the number of progenitor and glomus cells were preserved in the CBs of human subjects of advanced age. As reported for other mammalian species, glomus cells responded to hypoxia by external Ca(2+)-dependent increase of cytosolic [Ca(2+)] and quantal catecholamine release. Human glomus cells are also responsive to hypoglycemia and together the two stimuli, hypoxia and hypoglycemia, can potentiate each other's effects. The chemo-sensory responses of glomus cells are also preserved at an advanced age. Interestingly, a neurogenic niche similar to that recently described in rodents is also preserved in the adult human CB. These new data on the cellular and molecular physiology of the CB pave the way for future pathophysiological studies involving this organ in humans. |
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Student > Bachelor | 3 | 18% |
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Student > Postgraduate | 1 | 6% |
Other | 0 | 0% |
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