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γδTFH cells promote B cell maturation and antibody production in neuroblastoma

Overview of attention for article published in BMC Immunology, July 2017
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Title
γδTFH cells promote B cell maturation and antibody production in neuroblastoma
Published in
BMC Immunology, July 2017
DOI 10.1186/s12865-017-0216-x
Pubmed ID
Authors

Wenjun Mou, Wei Han, Xiaoli Ma, Xiaolin Wang, Hong Qin, Wen Zhao, Xiaoya Ren, Xi Chen, Wei Yang, Haiyan Cheng, Xisi Wang, Hui Zhang, Xin Ni, Huanmin Wang, Jingang Gui

Abstract

Previous studies have shown that γδ TFH cells are capable of modulating antibody production in immunized and infected mouse model. In recent studies, human γδ TFH cells are shown to contribute to the activation of humoral immunity and promote the maturation of B cells. However, little information is available on their involvement in neuroblastoma (NB) pathogenesis. In the present study, the frequency of γδ TFH cells in 74 NB patients was significantly higher compared with that in 60 healthy controls. Moreover, most γδ TFH cells in NB patients had a naive phenotype with up-regulation of CD25, CD69, HLA-DR and CD40L and down-regulation of ICOS. Importantly, γδ TFH cells in NB patients produced more IL-4 and IL-10 than those in healthy controls. Furthermore, serum total IgG level was significantly increased in NB patients compared with healthy controls. The expression of CD23 on B cells was up-regulated while CD80 expression was significantly down-regulated in NB patients. Further analysis of B cell compartment showed that the frequency of CD19(+)CD27(hi) plasma cells was enhanced in NB patients. Spearman's correlation analysis revealed that the frequency of γδ TFH cells was positively correlated to serum total IgG level and CD19(+)CD27(hi) plasma cells in NB patients, but negatively correlated to CD19(+) B cells. We concluded that γδ TFH cells might promote B cell maturation and antibody production in NB patients.

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X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 2 15%
Lecturer > Senior Lecturer 1 8%
Professor 1 8%
Student > Bachelor 1 8%
Researcher 1 8%
Other 1 8%
Unknown 6 46%
Readers by discipline Count As %
Immunology and Microbiology 3 23%
Computer Science 1 8%
Biochemistry, Genetics and Molecular Biology 1 8%
Medicine and Dentistry 1 8%
Chemistry 1 8%
Other 0 0%
Unknown 6 46%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2017.
All research outputs
#14,070,926
of 22,986,950 outputs
Outputs from BMC Immunology
#252
of 589 outputs
Outputs of similar age
#168,427
of 313,004 outputs
Outputs of similar age from BMC Immunology
#8
of 16 outputs
Altmetric has tracked 22,986,950 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 589 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,004 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.