Chapter title |
Influence of Free Radicals on the Intrinsic MRI Relaxation Properties
|
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Chapter number | 11 |
Book title |
Oxygen Transport to Tissue XXXIX
|
Published in |
Advances in experimental medicine and biology, July 2017
|
DOI | 10.1007/978-3-319-55231-6_11 |
Pubmed ID | |
Book ISBNs |
978-3-31-955229-3, 978-3-31-955231-6
|
Authors |
Rong-Wen Tain, Alessandro M. Scotti, Weiguo Li, Xiaohong Joe Zhou, Kejia Cai |
Abstract |
Free radicals are critical contributors in various conditions including normal aging, Alzheimer's disease, cancer, and diabetes. Currently there is no non-invasive approach to image tissue free radicals based on endogenous contrast due to their extremely short lifetimes and low in vivo concentrations. In this study we aim at characterizing the influence of free radicals on the MRI relaxation properties. Phantoms containing free radicals were created by treating egg white with various H 2 O 2 concentrations and scanned on a 9.4 T MRI scanner at room temperature. T1 and T2 relaxation maps were generated from data acquired with an inversion recovery sequence with varied inversion times and a multi-echo spin echo sequence with varied echo times (TEs), respectively. Results demonstrated that free radicals express a strong shortening effect on T1, which was proportional to the H 2 O 2 concentration, and a relatively small reduction in T2 (<10%). Furthermore, the sensitivity of this approach in the detection of free radicals was estimated to be in the pM range that is within the physiological range of in vivo free radical expression. In conclusion, the free radicals show a strong paramagnetic effect that may be utilized as an endogenous MRI contrast for its non-invasive in vivo imaging. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Unspecified | 1 | 9% |
Other | 1 | 9% |
Student > Doctoral Student | 1 | 9% |
Student > Bachelor | 1 | 9% |
Professor | 1 | 9% |
Other | 3 | 27% |
Unknown | 3 | 27% |
Readers by discipline | Count | As % |
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Unspecified | 1 | 9% |
Business, Management and Accounting | 1 | 9% |
Immunology and Microbiology | 1 | 9% |
Social Sciences | 1 | 9% |
Medicine and Dentistry | 1 | 9% |
Other | 1 | 9% |
Unknown | 5 | 45% |