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Oxygen Transport to Tissue XXXIX

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Cover of 'Oxygen Transport to Tissue XXXIX'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Oxygen Sensing by the Carotid Body: Past and Present
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    Chapter 2 Predicted Decrease in Membrane Oxygen Permeability with Addition of Cholesterol
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    Chapter 3 Chronic Diseases as Barriers to Oxygen Delivery: A Unifying Hypothesis of Tissue Reoxygenation Therapy
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    Chapter 4 Dorsiflexor Muscle Oxygenation During Low, Moderate and Submaximal Sustained Isometric Contraction
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    Chapter 5 Factors Determining the Oxygen Permeability of Biological Membranes: Oxygen Transport Across Eye Lens Fiber-Cell Plasma Membranes
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    Chapter 6 Multi-site Measurements of Muscle O2 Dynamics During Cycling Exercise in Early Post-myocardial Infarction
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    Chapter 7 Effects of 8 Weeks’ Training on Systemic and Muscle Oxygen Dynamics in University Rugby Players
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    Chapter 8 Imaging Redox State in Mouse Muscles of Different Ages
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    Chapter 9 Amino Acid Hydration Decreases Radiation-Induced Nausea in Mice: A Pica Model
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    Chapter 10 Evaluation of Haemoglobin and Cytochrome Responses During Forearm Ischaemia Using Multi-wavelength Time Domain NIRS
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    Chapter 11 Influence of Free Radicals on the Intrinsic MRI Relaxation Properties
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    Chapter 12 Inter-individual Differences in Exercise-Induced Spatial Working Memory Improvement: A Near-Infrared Spectroscopy Study
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    Chapter 13 Tumor Oxygenation Status: Facts and Fallacies
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    Chapter 14 Multiparametric Analysis of the Tumor Microenvironment: Hypoxia Markers and Beyond
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    Chapter 15 Computational Simulation of Tumor Hypoxia Based on In Vivo Microvasculature Assessed in a Dorsal Skin Window Chamber
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    Chapter 16 Hypoxia-Related Tumor Acidosis Affects MicroRNA Expression Pattern in Prostate and Breast Tumor Cells
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    Chapter 17 Cortical and Autonomic Stress Responses in Adults with High Versus Low Levels of Trait Anxiety: A Pilot Study
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    Chapter 18 Relation Between EEG Activity and Brain Oxygenation in Preterm Neonates
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    Chapter 19 Functional NIRS Measurement of Cytochrome-C-Oxidase Demonstrates a More Brain-Specific Marker of Frontal Lobe Activation Compared to the Haemoglobins
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    Chapter 20 Brain Tissue PO2 Measurement During Normoxia and Hypoxia Using Two-Photon Phosphorescence Lifetime Microscopy
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    Chapter 21 Age-Related Changes in Physiological Reactivity to a Stress Task: A Near-Infrared Spectroscopy Study
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    Chapter 22 Development and Validation of a Sensor Prototype for Near-Infrared Imaging of the Newborn Brain
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    Chapter 23 Directional Migration of MDA-MB-231 Cells Under O2/pH Gradients
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    Chapter 24 Environmental Enrichment Induces Increased Cerebral Capillary Density and Improved Cognitive Function in Mice
  26. Altmetric Badge
    Chapter 25 Improving Retinal Image Quality Using Registration with an SIFT Algorithm in Quasi-Confocal Line Scanning Ophthalmoscope
  27. Altmetric Badge
    Chapter 26 A New Method Based on Graphics Processing Units for Fast Near-Infrared Optical Tomography
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    Chapter 27 PFC Blood Oxygenation Changes in Four Different Cognitive Tasks
  29. Altmetric Badge
    Chapter 28 Diet-Induced Ketosis Protects Against Focal Cerebral Ischemia in Mouse
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    Chapter 29 Evaluation of Pleasure-Displeasure Induced by Use of Lipsticks with Near-Infrared Spectroscopy (NIRS): Usefulness of 2-Channel NIRS in Neuromarketing
  31. Altmetric Badge
    Chapter 30 Relationships Between Gum Chewing and Stroop Test: A Pilot Study
  32. Altmetric Badge
    Chapter 31 Effects of Motor Imagery on Cognitive Function and Prefrontal Cortex Activity in Normal Adults Evaluated by NIRS
  33. Altmetric Badge
    Chapter 32 Site Specificity of Changes in Cortical Oxyhaemoglobin Concentration Induced by Water Immersion
  34. Altmetric Badge
    Chapter 33 Changes in Oxyhemoglobin Concentration in the Prefrontal Cortex and Primary Motor Cortex During Low- and Moderate-Intensity Exercise on a Cycle Ergometer
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    Chapter 34 Tissue Blood Volume Parameters Measured by Continuous-Wave and Spatially Resolved NIRS Show Different Changes During Prolonged Cycling Exercise
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    Chapter 35 Delayed Onset of Reoxygenation in Inactive Muscles After High-Intensity Exercise
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    Chapter 36 Cortical Oxyhemoglobin Elevation Persists After Moderate-Intensity Cycling Exercise: A Near-Infrared Spectroscopy Study
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    Chapter 37 Relation Between Cognitive Function and Baseline Concentrations of Hemoglobin in Prefrontal Cortex of Elderly People Measured by Time-Resolved Near-Infrared Spectroscopy
  39. Altmetric Badge
    Chapter 38 Physiological Effects of Continuous Colored Light Exposure on Mayer Wave Activity in Cerebral Hemodynamics: A Functional Near-Infrared Spectroscopy (fNIRS) Study
  40. Altmetric Badge
    Chapter 39 Electron Paramagnetic Resonance pO2 Image Tumor Oxygen-Guided Radiation Therapy Optimization
  41. Altmetric Badge
    Chapter 40 Using India Ink as a Sensor for Oximetry: Evidence of its Safety as a Medical Device
  42. Altmetric Badge
    Chapter 41 Measurement of pO2 in a Pre-clinical Model of Rabbit Tumor Using OxyChip, a Paramagnetic Oxygen Sensor
  43. Altmetric Badge
    Chapter 42 Correlation Between Hypoxia Proteins and EPR-Detected Hypoxia in Tumors
  44. Altmetric Badge
    Chapter 43 Triarylmethyl Radical OX063d24 Oximetry: Electron Spin Relaxation at 250 MHz and RF Frequency Dependence of Relaxation and Signal-to-Noise
  45. Altmetric Badge
    Chapter 44 In Vivo EPR Resolution Enhancement Using Techniques Known from Quantum Computing Spin Technology
  46. Altmetric Badge
    Chapter 45 Hemoglobin-Based Oxygen Carrier (HBOC) Development in Trauma: Previous Regulatory Challenges, Lessons Learned, and a Path Forward
  47. Altmetric Badge
    Chapter 46 The Penultimate Tyrosine Residues are Critical for the Genotoxic Effect of Human Hemoglobin
  48. Altmetric Badge
    Chapter 47 Methemoglobin: A New Way to Distinguish Burn Depth
  49. Altmetric Badge
    Chapter 48 Characterization of Protein-Protein Interactions in Recombinant Hemoglobin Producing Escherichia coli Cells Using Molecularly Imprinted Polymers
  50. Altmetric Badge
    Chapter 49 Tissue-Integrating Oxygen Sensors: Continuous Tracking of Tissue Hypoxia
  51. Altmetric Badge
    Chapter 50 Optical Design of Adaptive Optics Confocal Scanning Laser Ophthalmoscope with Two Deformable Mirrors
  52. Altmetric Badge
    Chapter 51 Construction of 0.15 Tesla Overhauser Enhanced MRI
  53. Altmetric Badge
    Chapter 52 Gold Nanoparticle-Based Fluorescent Contrast Agent with Enhanced Sensitivity
  54. Altmetric Badge
    Chapter 53 Potential Erythropoiesis in the Primo-Vascular System in Heart Failure
  55. Altmetric Badge
    Chapter 54 Quantitative Biology of Exercise-Induced Signal Transduction Pathways
Attention for Chapter 16: Hypoxia-Related Tumor Acidosis Affects MicroRNA Expression Pattern in Prostate and Breast Tumor Cells
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Chapter title
Hypoxia-Related Tumor Acidosis Affects MicroRNA Expression Pattern in Prostate and Breast Tumor Cells
Chapter number 16
Book title
Oxygen Transport to Tissue XXXIX
Published in
Advances in experimental medicine and biology, July 2017
DOI 10.1007/978-3-319-55231-6_16
Pubmed ID
Book ISBNs
978-3-31-955229-3, 978-3-31-955231-6
Authors

A. Riemann, S. Reime, O. Thews, Riemann, A., Reime, S., Thews, O.

Abstract

MicroRNAs (miRNAs) are small non-coding RNA sequences which are able to modulate the expression of many functional proteins. The expression level of miRNAs can be modulated by parameters of the tumor microenvironment like hypoxia, nutrient deprivation or oxidative stress. Since miRNAs can act either as oncogenes or tumor suppressors, this may affect malignant progression or therapy resistance. In the present study it was analyzed whether extracellular acidosis can impact on miRNA expression. Therefore, tumor cells (R3327-AT-1 prostate and Walker-256 mammary carcinoma cells) were incubated at pH 6.6 (acidosis) or pH 7.4 (control) for 24 h and changes in miRNA expression were analyzed by PCR array for 84 cancer-associated miRNAs and Next-Generation Sequencing (NGS) with a panel of 765 miRNAs.In the cancer-related PCR array an acidosis-induced reduction of 5 miRNAs in AT-1 and 6 miRNAs in Walker-256 cells was seen. The miR-203a was consensually down-regulated in both cell lines. Using NGS, 19 miRNAs were found to be upregulated and 14 miRNAS were downregulated in AT-1 prostate cancer cells. In Walker-256 cells the expression of 21 miRNAs was increased and decreased for 17 miRNAs. Eleven miRNAs were regulated by acidosis in both tumor cell lines in the same direction.Acidosis induced changes in the miRNA expression of prostate and breast carcinoma cells. However, miRNA profiles differed strongly between the tumor cell lines (and between the experimental methods used), indicating that cells can react individually to microenvironmental stress. However, some miRNAs were consensually regulated in both cell lines and thus might represent a general cellular response to an extracellular acidosis.

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Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 50%
Student > Master 1 13%
Unknown 3 38%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 25%
Computer Science 1 13%
Unknown 5 63%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2017.
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#9,192,740
of 11,483,620 outputs
Outputs from Advances in experimental medicine and biology
#1,781
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Outputs of similar age
#189,571
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Outputs of similar age from Advances in experimental medicine and biology
#2
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