Chapter title |
Relation Between Cognitive Function and Baseline Concentrations of Hemoglobin in Prefrontal Cortex of Elderly People Measured by Time-Resolved Near-Infrared Spectroscopy
|
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Chapter number | 37 |
Book title |
Oxygen Transport to Tissue XXXIX
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Published in |
Advances in experimental medicine and biology, July 2017
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DOI | 10.1007/978-3-319-55231-6_37 |
Pubmed ID | |
Book ISBNs |
978-3-31-955229-3, 978-3-31-955231-6
|
Authors |
Y. Murayama, Y. Sato, L. Hu, A. Brugnera, A. Compare, Kaoru Sakatani |
Abstract |
We evaluated relationship between cognitive function and cerebral blood oxygenation (CBO) of the prefrontal cortex (PFC) at rest in 113 adults (age 72.3 ± 12.0 years). We employed a two channel time-resolved near-infrared spectroscopy (TRS), which allows non-invasive measurements of baseline concentrations of oxyhemoglobin (oxy-Hb), deoxyhemoglobin (deoxy-Hb), total-hemoglobin (t-Hb) (μM) and oxygen saturation (SO2, %) of the bilateral PFC without any tasks. We examined cognitive functions using the Mini-Mental State Examination (MMSE) (range from 0 to 30) and the Touch M which evaluates working memory function semi-automatically on a touchscreen (range from 0 to 100); the mean MMSE and Touch M scores of all subjects were 24.8 ± 4.6 (mean ± SD; range 11-30) and 41.3 ± 22.1 (range 1-100), respectively. Employing Pearson's correlation analysis, we evaluated correlation between the TRS parameters and cognitive function. We found a significant positive correlation between the MMSE scores and SO2 (r = 0.24, p < 0.02). In addition, we observed significant positive correlations between Touch M scores and baseline concentrations of oxy-Hb (r = 0.26, p < 0.02), total-Hb (r = 0.23, p < 0.05), and SO2 (r = 0.23, p < 0.05). TRS allowed us to evaluate the relation between CBO in the PFC at rest and cognitive function. |
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Geographical breakdown
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Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 29% |
Researcher | 3 | 18% |
Student > Postgraduate | 2 | 12% |
Student > Master | 2 | 12% |
Other | 1 | 6% |
Other | 0 | 0% |
Unknown | 4 | 24% |
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Psychology | 2 | 12% |
Neuroscience | 2 | 12% |
Social Sciences | 1 | 6% |
Other | 2 | 12% |
Unknown | 4 | 24% |