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Outcome of patients with septic shock and high-dose vasopressor therapy

Overview of attention for article published in Annals of Intensive Care, April 2017
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

Mentioned by

blogs
1 blog
twitter
5 tweeters
wikipedia
1 Wikipedia page

Citations

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51 Dimensions

Readers on

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80 Mendeley
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Title
Outcome of patients with septic shock and high-dose vasopressor therapy
Published in
Annals of Intensive Care, April 2017
DOI 10.1186/s13613-017-0261-x
Pubmed ID
Authors

Thomas Auchet, Marie-Alix Regnier, Nicolas Girerd, Bruno Levy

Abstract

Despite the dissemination of international guidelines, mortality from septic shock remains high. Norepinephrine is recommended as first-line vasopressor therapy with a target mean arterial pressure of 65 mmHg. High-dose vasopressor (HDV) may also be required. This study aimed to assess survival in patients with septic shock requiring HDV. We conducted a retrospective study of patients admitted between January 2008 and December 2013 to a 13-bed ICU for septic shock and receiving high-dose vasopressor therapy (defined by a dose >1 µg/kg/min). Primary outcome was 28-day mortality (D28). Secondary outcomes were 90-day mortality (D90), organ failure score (SOFA), duration of organ failure, duration and dosage of vasopressor agent and ischemic complications. In our cohort of 106 patients, mortality reached 60.4% at D28 and 66.3% at D90. One in two patients died before D10. The weight-based mean dose of vasopressor (WMD) represented the best prognostic factor. Using a cutoff of 0.75 µg/kg/min, WMD was associated with mortality with a sensitivity of 73% and specificity of 74%. The mortality rate reached 86.4% when WMD was above the cutoff value and associated with a SOFA score >10. Digital or limb necrosis was documented in 6 patients (5.7%). In total, 40% of septic shock patients receiving high-dose vasopressor therapy survived at day 28 after admission. A WMD cutoff value of 0.75 µg/kg/min, associated with a >10 SOFA score, was a strong predictor of death. These results provide insights into outcome of refractory septic shock, showing that administration of high-dose vasopressor may indeed be useful in these patients.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 1%
Unknown 79 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 14%
Student > Postgraduate 9 11%
Other 8 10%
Student > Ph. D. Student 8 10%
Professor 6 8%
Other 17 21%
Unknown 21 26%
Readers by discipline Count As %
Medicine and Dentistry 39 49%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Nursing and Health Professions 3 4%
Veterinary Science and Veterinary Medicine 2 3%
Computer Science 2 3%
Other 8 10%
Unknown 23 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 February 2020.
All research outputs
#1,567,194
of 16,975,484 outputs
Outputs from Annals of Intensive Care
#156
of 773 outputs
Outputs of similar age
#38,137
of 272,044 outputs
Outputs of similar age from Annals of Intensive Care
#3
of 9 outputs
Altmetric has tracked 16,975,484 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 773 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.0. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 272,044 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.