Title |
Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report
|
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Published in |
Nutrition & Metabolism, April 2010
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DOI | 10.1186/1743-7075-7-33 |
Pubmed ID | |
Authors |
Giulio Zuccoli, Norina Marcello, Anna Pisanello, Franco Servadei, Salvatore Vaccaro, Purna Mukherjee, Thomas N Seyfried |
Abstract |
Management of glioblastoma multiforme (GBM) has been difficult using standard therapy (radiation with temozolomide chemotherapy). The ketogenic diet is used commonly to treat refractory epilepsy in children and, when administered in restricted amounts, can also target energy metabolism in brain tumors. We report the case of a 65-year-old woman who presented with progressive memory loss, chronic headaches, nausea, and a right hemisphere multi-centric tumor seen with magnetic resonance imaging (MRI). Following incomplete surgical resection, the patient was diagnosed with glioblastoma multiforme expressing hypermethylation of the MGMT gene promoter. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 9 | 26% |
United Kingdom | 2 | 6% |
Spain | 2 | 6% |
South Africa | 1 | 3% |
Ireland | 1 | 3% |
Japan | 1 | 3% |
Canada | 1 | 3% |
Unknown | 17 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 21 | 62% |
Practitioners (doctors, other healthcare professionals) | 9 | 26% |
Scientists | 4 | 12% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 1% |
Israel | 1 | <1% |
Canada | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 359 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 86 | 23% |
Student > Bachelor | 57 | 16% |
Student > Ph. D. Student | 37 | 10% |
Researcher | 36 | 10% |
Student > Postgraduate | 19 | 5% |
Other | 57 | 16% |
Unknown | 74 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 105 | 29% |
Agricultural and Biological Sciences | 46 | 13% |
Nursing and Health Professions | 40 | 11% |
Biochemistry, Genetics and Molecular Biology | 28 | 8% |
Neuroscience | 19 | 5% |
Other | 43 | 12% |
Unknown | 85 | 23% |