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α4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets

Overview of attention for article published in Acta Neuropathologica Communications, March 2014
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1 tweeter

Citations

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Title
α4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets
Published in
Acta Neuropathologica Communications, March 2014
DOI 10.1186/2051-5960-2-27
Pubmed ID
Authors

Veit Rothhammer, Andreas Muschaweckh, Georg Gasteiger, Franziska Petermann, Sylvia Heink, Dirk H Busch, Mathias Heikenwälder, Bernhard Hemmer, Ingo Drexler, Thomas Korn

Abstract

Natalizumab blocks α4-integrins and is a prototypic agent for a series of anti-inflammatory drugs that impair trafficking of immune cells into the CNS. However, modulation of the access of immune cells to the CNS is associated with impaired immune surveillance and detrimental viral infections of the CNS. Here, we explored the potency of cellular immune responses within the CNS to protect against viral encephalitis in mice with T cell conditional disruption of VLA-4 integrin (α4β1) expression.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 22%
Researcher 6 22%
Student > Master 4 15%
Student > Doctoral Student 2 7%
Other 2 7%
Other 4 15%
Unknown 3 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 30%
Immunology and Microbiology 7 26%
Medicine and Dentistry 4 15%
Neuroscience 3 11%
Biochemistry, Genetics and Molecular Biology 2 7%
Other 0 0%
Unknown 3 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2014.
All research outputs
#3,039,908
of 4,507,778 outputs
Outputs from Acta Neuropathologica Communications
#123
of 186 outputs
Outputs of similar age
#71,249
of 107,280 outputs
Outputs of similar age from Acta Neuropathologica Communications
#14
of 24 outputs
Altmetric has tracked 4,507,778 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 186 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 107,280 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.