Title |
Inhibitors of apoptosis proteins in experimental benign prostatic hyperplasia: effects of serenoa repens, selenium and lycopene
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Published in |
Journal of Biomedical Science, March 2014
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DOI | 10.1186/1423-0127-21-19 |
Pubmed ID | |
Authors |
Letteria Minutoli, Domenica Altavilla, Herbert Marini, Mariagrazia Rinaldi, Natasha Irrera, Gabriele Pizzino, Alessandra Bitto, Salvatore Arena, Sebastiano Cimino, Francesco Squadrito, Giorgio Ivan Russo, Giuseppe Morgia |
Abstract |
The apoptosis machinery is a promising target against benign prostatic hyperplasia (BPH). Inhibitors of apoptosis proteins (IAPs) modulate apoptosis by direct inhibition of caspases. Serenoa Repens (SeR) may be combined with other natural compounds such as Lycopene (Ly) and Selenium (Se) to maximize its therapeutic activity in BPH. We investigated the effects of SeR, Se and Ly, alone or in association, on the expression of four IAPs, cIAP-1, cIAP-2, NAIP and survivin in rats with experimental testosterone-dependent BPH. Moreover, caspase-3, interleukin-6 (IL-6) and prostate specific membrane antigen (PSMA) have been evaluated.Rats were administered, daily, with testosterone propionate (3 mg/kg/sc) or its vehicle for 14 days. Testosterone injected animals (BPH) were randomized to receive vehicle, SeR (25 mg/kg/sc), Se (3 mg/kg/sc), Ly (1 mg/kg/sc) or the SeR-Se-Ly association for 14 days. Animals were sacrificed and prostate removed for analysis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
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Italy | 1 | 1% |
Unknown | 71 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 17 | 24% |
Researcher | 13 | 18% |
Student > Master | 11 | 15% |
Other | 8 | 11% |
Student > Ph. D. Student | 5 | 7% |
Other | 12 | 17% |
Unknown | 6 | 8% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 20 | 28% |
Pharmacology, Toxicology and Pharmaceutical Science | 10 | 14% |
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Biochemistry, Genetics and Molecular Biology | 3 | 4% |
Other | 9 | 13% |
Unknown | 13 | 18% |