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Inhibitors of apoptosis proteins in experimental benign prostatic hyperplasia: effects of serenoa repens, selenium and lycopene

Overview of attention for article published in Journal of Biomedical Science, March 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (72nd percentile)

Mentioned by

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2 tweeters
patent
1 patent

Citations

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27 Dimensions

Readers on

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57 Mendeley
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Title
Inhibitors of apoptosis proteins in experimental benign prostatic hyperplasia: effects of serenoa repens, selenium and lycopene
Published in
Journal of Biomedical Science, March 2014
DOI 10.1186/1423-0127-21-19
Pubmed ID
Authors

Letteria Minutoli, Domenica Altavilla, Herbert Marini, Mariagrazia Rinaldi, Natasha Irrera, Gabriele Pizzino, Alessandra Bitto, Salvatore Arena, Sebastiano Cimino, Francesco Squadrito, Giorgio Ivan Russo, Giuseppe Morgia

Abstract

The apoptosis machinery is a promising target against benign prostatic hyperplasia (BPH). Inhibitors of apoptosis proteins (IAPs) modulate apoptosis by direct inhibition of caspases. Serenoa Repens (SeR) may be combined with other natural compounds such as Lycopene (Ly) and Selenium (Se) to maximize its therapeutic activity in BPH. We investigated the effects of SeR, Se and Ly, alone or in association, on the expression of four IAPs, cIAP-1, cIAP-2, NAIP and survivin in rats with experimental testosterone-dependent BPH. Moreover, caspase-3, interleukin-6 (IL-6) and prostate specific membrane antigen (PSMA) have been evaluated.Rats were administered, daily, with testosterone propionate (3 mg/kg/sc) or its vehicle for 14 days. Testosterone injected animals (BPH) were randomized to receive vehicle, SeR (25 mg/kg/sc), Se (3 mg/kg/sc), Ly (1 mg/kg/sc) or the SeR-Se-Ly association for 14 days. Animals were sacrificed and prostate removed for analysis.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 2%
Korea, Republic of 1 2%
Unknown 55 96%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 28%
Researcher 11 19%
Student > Master 9 16%
Other 6 11%
Student > Ph. D. Student 4 7%
Other 9 16%
Unknown 2 4%
Readers by discipline Count As %
Medicine and Dentistry 18 32%
Pharmacology, Toxicology and Pharmaceutical Science 7 12%
Nursing and Health Professions 7 12%
Agricultural and Biological Sciences 6 11%
Biochemistry, Genetics and Molecular Biology 3 5%
Other 8 14%
Unknown 8 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2018.
All research outputs
#4,376,112
of 15,900,481 outputs
Outputs from Journal of Biomedical Science
#157
of 769 outputs
Outputs of similar age
#50,557
of 190,282 outputs
Outputs of similar age from Journal of Biomedical Science
#2
of 4 outputs
Altmetric has tracked 15,900,481 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 769 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 190,282 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.