Title |
A phase I study of combination vaccine treatment of five therapeutic epitope-peptides for metastatic colorectal cancer; safety, immunological response, and clinical outcome
|
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Published in |
Journal of Translational Medicine, March 2014
|
DOI | 10.1186/1479-5876-12-63 |
Pubmed ID | |
Authors |
Shoichi Hazama, Yusuke Nakamura, Hiroko Takenouchi, Nobuaki Suzuki, Ryouichi Tsunedomi, Yuka Inoue, Yoshihiro Tokuhisa, Norio Iizuka, Shigefumi Yoshino, Kazuyoshi Takeda, Hirokazu Shinozaki, Akira Kamiya, Hiroyuki Furukawa, Masaaki Oka |
Abstract |
To evaluate the safety of combination vaccine treatment of multiple peptides, phase I clinical trial was conducted for patients with advanced colorectal cancer using five novel HLA-A*2402-restricted peptides, three peptides derived from oncoantigens, ring finger protein 43 (RNF43), 34 kDa-translocase of the outer mitochondrial membrane (TOMM34), and insulin-like growth factor-II mRNA binding protein 3 (KOC1), and the remaining two from angiogenesis factors, vascular endothelial growth factor receptor 1 (VEGFR1) and VEGFR2. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 50% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 78 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 14% |
Student > Master | 11 | 14% |
Student > Ph. D. Student | 9 | 12% |
Student > Bachelor | 8 | 10% |
Other | 8 | 10% |
Other | 12 | 15% |
Unknown | 19 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 23 | 29% |
Biochemistry, Genetics and Molecular Biology | 13 | 17% |
Agricultural and Biological Sciences | 8 | 10% |
Immunology and Microbiology | 6 | 8% |
Chemical Engineering | 2 | 3% |
Other | 6 | 8% |
Unknown | 20 | 26% |